| pubmed-article:10817732 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10817732 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:10817732 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10817732 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:10817732 | lifeskim:mentions | umls-concept:C0014806 | lld:lifeskim |
| pubmed-article:10817732 | lifeskim:mentions | umls-concept:C0028902 | lld:lifeskim |
| pubmed-article:10817732 | lifeskim:mentions | umls-concept:C0069906 | lld:lifeskim |
| pubmed-article:10817732 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:10817732 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10817732 | pubmed:dateCreated | 2000-7-11 | lld:pubmed |
| pubmed-article:10817732 | pubmed:abstractText | To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump. | lld:pubmed |
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| pubmed-article:10817732 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10817732 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10817732 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10817732 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10817732 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10817732 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:OkiEE | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:KohnoSS | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:NoguchiYY | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:FukudaMM | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:ShiozawaKK | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:SuenagaMM | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:TsukamotoKK | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:TeiCC | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:TerashiKK | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:KawabataSS | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:SodaHH | lld:pubmed |
| pubmed-article:10817732 | pubmed:author | pubmed-author:NakatomiKK | lld:pubmed |
| pubmed-article:10817732 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10817732 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:10817732 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10817732 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10817732 | pubmed:pagination | 1697-700 | lld:pubmed |
| pubmed-article:10817732 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10817732 | pubmed:meshHeading | pubmed-meshheading:10817732... | lld:pubmed |
| pubmed-article:10817732 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10817732 | pubmed:articleTitle | Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells. | lld:pubmed |
| pubmed-article:10817732 | pubmed:affiliation | Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. | lld:pubmed |
| pubmed-article:10817732 | pubmed:publicationType | Journal Article | lld:pubmed |
| literatureCitation:862_1081... | literatureCitation:pubmed | pubmed-article:10817732 | lld:drugbank |
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