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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2000-7-11
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pubmed:abstractText |
To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythromycin enhanced sensitivity with increased intracellular vincristine accumulation and inhibited the calcein-AM efflux. Our findings suggest that the two agents are possible MRP substrates and may competitively inhibit MRP function as a drug efflux pump.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-10097135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-10331089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-1687171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-2175794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-2568347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-6606682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-7669559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-7909692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-8102521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-8534927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-8644864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-8712746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-8763335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9131486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9152603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9248661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9270026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9333032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9435299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9473310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9527807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9695727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9822896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817732-9892204
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0066-4804
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pubmed:author |
pubmed-author:FukudaMM,
pubmed-author:KawabataSS,
pubmed-author:KohnoSS,
pubmed-author:NakamuraTT,
pubmed-author:NakatomiKK,
pubmed-author:NoguchiYY,
pubmed-author:OkiEE,
pubmed-author:ShiozawaKK,
pubmed-author:SodaHH,
pubmed-author:SuenagaMM,
pubmed-author:TeiCC,
pubmed-author:TerashiKK,
pubmed-author:TsukamotoKK
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1697-700
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10817732-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10817732-Drug Interactions,
pubmed-meshheading:10817732-Erythromycin,
pubmed-meshheading:10817732-Fluoresceins,
pubmed-meshheading:10817732-Genes, MDR,
pubmed-meshheading:10817732-Humans,
pubmed-meshheading:10817732-Leukemia,
pubmed-meshheading:10817732-Ofloxacin,
pubmed-meshheading:10817732-P-Glycoprotein,
pubmed-meshheading:10817732-Tumor Cells, Cultured,
pubmed-meshheading:10817732-Vincristine
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pubmed:year |
2000
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pubmed:articleTitle |
Interactions of ofloxacin and erythromycin with the multidrug resistance protein (MRP) in MRP-overexpressing human leukemia cells.
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pubmed:affiliation |
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
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pubmed:publicationType |
Journal Article
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