Linked Life Data

10817709

Source:http://linkedlifedata.com/resource/pubmed/id/10817709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-7-11
pubmed:abstractText
Macrolide resistance in Streptococcus pneumoniae has been associated with two main mechanisms: target modification by Erm methyltransferases and efflux by macrolide pumps. The ketolide ABT-773, which has a 3-keto group and no L-cladinose sugar, represents a new class of drugs with in vitro activity against a variety of resistant bacteria. Several approaches were undertaken to understand how ABT-773 was able to defeat resistance mechanisms. We demonstrated tighter ribosome binding of ABT-773 than erythromycin. We also showed that ABT-773 (i) accumulated in macrolide-sensitive S. pneumoniae at a higher rate than erythromycin, (ii) was able to bind with methylated ribosomes, though at lower affinities than with wild-type ribosomes, and (iii) accumulated in S. pneumoniae strains with the efflux-resistant phenotype.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-10524961, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-10639382, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-2159256, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-2178338, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-2506804, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-4966821, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-7354244, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-7793855, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-8843287, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-8985659, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-8987357, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-9333056, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817709-9736575
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1562-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae.
pubmed:affiliation
Infectious Disease Research, Abbott Laboratories, Abbott Park, Illinois 60064-6217, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't