Linked Life Data

10817693

Source:http://linkedlifedata.com/resource/pubmed/id/10817693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-7-11
pubmed:abstractText
Previous experiments with rifalazil (RLZ) (also known as KRM-1648) in combination with isoniazid (INH) demonstrated its potential for short-course treatment of Mycobacterium tuberculosis infection. In this study we investigated the minimum RLZ-INH treatment time required to eradicate M. tuberculosis in a murine model. RLZ-INH treatment for 6 weeks or longer led to a nonculturable state. Groups of mice treated in parallel were killed following an observation period to evaluate regrowth. RLZ-INH treatment for a minimum of 10 weeks was necessary to maintain a nonculturable state through the observation period. Pyrazinamide (PZA) was added to this regimen to determine whether the treatment duration could be further reduced. In this model, the addition of PZA did not shorten the duration of RLZ-INH treatment required to eradicate M. tuberculosis from mice. The addition of PZA reduced the number of mice in which regrowth occurred, although the reduction was not statistically significant.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-375787, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-6386028, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-6508006, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-7065534, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-7840552, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-8762850, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-8834869, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-8834891, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-9124846, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-9562106, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-9603120, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817693-9797254
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1458-62
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Evaluation of rifalazil in long-term treatment regimens for tuberculosis in mice.
pubmed:affiliation
State University of New York Upstate Medical University, Veterans Affairs Medical Center, Syracuse, New York, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't