Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-7-11
pubmed:abstractText
Twenty (8.5%) of 234 nonrepetitive clinical isolates of Klebsiella pneumoniae from southern Taiwan were found to produce extended-spectrum beta-lactamases (ESBLs): 10 strains produced SHV-12, 4 produced SHV-5, 2 produced a non-TEM non-SHV ESBL with a pI of 8.3, 3 produced a novel AmpC beta-lactamase designated CMY-8 with a pI of 8.25, and 1 produced SHV-12 and an unidentified AmpC enzyme with a pI of 8.2. The CMY-8 enzyme confers a resistance phenotype similar to CMY-1 and MOX-1, and sequence comparisons showed high homologies (>95%) of nucleotide and amino acid sequences among these three enzymes. Plasmid and pulse-field gel electrophoresis analyses revealed that all isolates harboring an SHV-derived ESBL were genetically unrelated, indicating that dissemination of resistance plasmids is responsible for the spread of SHV ESBLs among K. pneumoniae in this area. All three isolates carrying CMY-8 had identical genotypic patterns, suggesting the presence of an epidemic strain.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-10390237, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-2221867, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-2276823, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-3263690, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-3538420, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-358200, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-6092432, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-7811049, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-7814497, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-7821300, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-807678, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-8112596, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-8787910, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-8793399, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-8815106, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-8843306, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-8889716, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-9056008, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-9087490, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-9145849, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-9574728, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-9705432, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-9710678, http://linkedlifedata.com/resource/pubmed/commentcorrection/10817689-9830274
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1438-42
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Prevalence of SHV-12 among clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases and identification of a novel AmpC enzyme (CMY-8) in Southern Taiwan.
pubmed:affiliation
Department of Pathology, National Cheng Kung University Medical Center, Tainan, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't