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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1976-3-1
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pubmed:abstractText |
Human bone marrow is known to contain significant numbers of bursa-dependent lymphocytes. The presence of thymus-dependent (T) cells is controversial. Bone marrow cells obtained from healthy volunteers was fractionated by density centrifugation. A lymphocte-enriched subpopulation was shown to be reactive to alloantigens in mixed lymphocyte culture and to contain substantial numbers of T lymphocytes. The T lymphocytes were detected by cell surface markers (rosette formation with sheep RBC) and by response to the mitogens phytohemagglutinin and concanavalin A. Bone marrow T cells exhibited functional characteristics quantitatively different from peripheral blood T cells, suggesting that they may represent a particular subpopulation of T cells. The lymphocyte-enriched fraction additionally contained committed granulopoietic stem cells capable of colony formation in semisolid gel. The presence of T cells in human bone marrow is consistent with findings in other mammals and may explain the high incidence of graft versus host disease in bone marrow transplant recipients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-235092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4106179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4108877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4115122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4118467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4134727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4147639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4179068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4181832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4188336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4266014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4396458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4403147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4527818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4544179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4580485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4594974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4596970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-4941661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5007911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5056579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5080423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5242204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5323079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5471041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5558561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1081550-5681022
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1491-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1081550-Adult,
pubmed-meshheading:1081550-Bone Marrow,
pubmed-meshheading:1081550-Bone Marrow Cells,
pubmed-meshheading:1081550-Cell Separation,
pubmed-meshheading:1081550-Cells, Cultured,
pubmed-meshheading:1081550-Centrifugation, Density Gradient,
pubmed-meshheading:1081550-Histocompatibility Testing,
pubmed-meshheading:1081550-Humans,
pubmed-meshheading:1081550-Immune Adherence Reaction,
pubmed-meshheading:1081550-Lymphocyte Activation,
pubmed-meshheading:1081550-T-Lymphocytes
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pubmed:year |
1975
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pubmed:articleTitle |
Thymus-dependent lymphocytes in human bone marrow.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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