Source:http://linkedlifedata.com/resource/pubmed/id/10814799
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2000-6-26
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| pubmed:abstractText |
In a longitudinal prospective study a muscle biopsy was taken from 30/32 (33%) of the 98 patients who developed critical illness polyneuropathy and myopathy (CIPNM). Neuropathic changes were found in 37%, myopathic in 40%, and a combination in 23% of the biopsies. The immunohistopathology showed macrophages and Th-cells in 40% and 60% of the muscle biopsies respectively. Small mainly perivascular infiltrates contained macrophages and Th-cells. ICAM-1, VCAM and MAC were found on the vascular endothelium in 58%, 53% and 79% respectively. In all biopsies there was an upregulation of both HLA-I and HLA-DR. Proinflammatory cytokines and TNFalphaR75 were also produced locally (IL-1beta in 71%, IFN-gamma in 40%, IL-12 in 73%, TNFalphaR75 in 90%). The anti-inflammatory cytokine IL-10 was simultaneously expressed in 96% of the biopsies. HLA-DR, TNFalphaR75 and IL-10 differed significantly when compared with control muscle biopsies. Our data provide evidence that small numbers of activated leukocytes producing both pro- and anti-inflammatory cytokines infiltrate skeletal muscle of CIPNM patients. We propose that the local balance of leukocyte activities is of importance in the pathophysiology of muscle weakness in CIPNM.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0165-5728
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
106
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
206-13
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10814799-Antigens, CD,
pubmed-meshheading:10814799-Critical Illness,
pubmed-meshheading:10814799-Cytokines,
pubmed-meshheading:10814799-HLA-DR Antigens,
pubmed-meshheading:10814799-Humans,
pubmed-meshheading:10814799-Immune System,
pubmed-meshheading:10814799-Immunohistochemistry,
pubmed-meshheading:10814799-Incidence,
pubmed-meshheading:10814799-Intercellular Adhesion Molecule-1,
pubmed-meshheading:10814799-Interleukin-10,
pubmed-meshheading:10814799-Longitudinal Studies,
pubmed-meshheading:10814799-Muscles,
pubmed-meshheading:10814799-Muscular Diseases,
pubmed-meshheading:10814799-Netherlands,
pubmed-meshheading:10814799-Polyneuropathies,
pubmed-meshheading:10814799-Prospective Studies,
pubmed-meshheading:10814799-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10814799-Receptors, Tumor Necrosis Factor, Type II
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| pubmed:year |
2000
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| pubmed:articleTitle |
Critical illness polyneuropathy and myopathy (CIPNM): evidence for local immune activation by cytokine-expression in the muscle tissue.
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| pubmed:affiliation |
Department of Neurology, St. Elisabeth Hospital Tilburg, Tilburg, The Netherlands. megens-deletter@wxs.nl
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| pubmed:publicationType |
Journal Article
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