| pubmed-article:10814713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10814713 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:10814713 | lifeskim:mentions | umls-concept:C0456603 | lld:lifeskim |
| pubmed-article:10814713 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:10814713 | lifeskim:mentions | umls-concept:C0034606 | lld:lifeskim |
| pubmed-article:10814713 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:10814713 | lifeskim:mentions | umls-concept:C0441633 | lld:lifeskim |
| pubmed-article:10814713 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10814713 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10814713 | pubmed:dateCreated | 2000-8-29 | lld:pubmed |
| pubmed-article:10814713 | pubmed:abstractText | Some studies show that plasma triglyceride (TG) levels are a significant independent risk factor for cardiovascular disease (CVD). TG levels are inversely correlated with high density lipoprotein cholesterol (HDL-C) levels, and their metabolism may be closely interrelated. Therefore, the TG/HDL-C ratio may be a relevant CVD risk factor. Our analysis of families in the Framingham Heart Study gave a genetic heritability estimate for log(TG) of 0.40 and for log(TG/HDL-C) of 0.49, demonstrating an important genetic component for both. A 10 cM genome-wide scan for log(TG) level and log(TG/HDL-C) was carried out for the largest 332 extended families of the Framingham Heart Study (1702 genotyped individuals). The highest multipoint variance component LOD scores obtained for both log(TG) and log(TG/HDL-C) were on chromosome 7 (at 155 cM), where the results for the two phenotypes were 1.8 and 2.5, respectively. The 7q32.3-qter region contains several candidate genes. Four other regions with multipoint LOD scores greater than one were identified on chromosome 3 [LOD score for log(TG/HDL-C) = 1.8 at 140 cM], chromosome 11 [LOD score for log(TG/HDL-C) = 1.1 at 125 cM], chromosome 16 [LOD score for log(TG) = 1.5 at 70 cM, LOD score for log(TG/HDL-C) = 1.1 at 75 cM] and chromosome 20 [LOD score for log(TG/HDL-C) = 1.7 at 35 cM, LOD score for log(TG) = 1.3 at 40 cM]. These results identify loci worthy of further study. | lld:pubmed |
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| pubmed-article:10814713 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10814713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10814713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10814713 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10814713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10814713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10814713 | pubmed:month | May | lld:pubmed |
| pubmed-article:10814713 | pubmed:issn | 0964-6906 | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:SchaeferE JEJ | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:MyersR HRH | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:HousmanD EDE | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:RAILG AGA | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:WilsonP WPW | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:OrdovasJ MJM | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:CupplesL ALA | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:DeStefanoA... | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:HarmonM DMD | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:ShearmanA MAM | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:JoostOO | lld:pubmed |
| pubmed-article:10814713 | pubmed:author | pubmed-author:KeenJ DJD | lld:pubmed |
| pubmed-article:10814713 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10814713 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:10814713 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:10814713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10814713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10814713 | pubmed:pagination | 1315-20 | lld:pubmed |
| pubmed-article:10814713 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10814713 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10814713 | pubmed:articleTitle | Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study. | lld:pubmed |
| pubmed-article:10814713 | pubmed:affiliation | Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, shearman@mit.edu | lld:pubmed |
| pubmed-article:10814713 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10814713 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10814713 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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