Source:http://linkedlifedata.com/resource/pubmed/id/10814713
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2000-8-29
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pubmed:abstractText |
Some studies show that plasma triglyceride (TG) levels are a significant independent risk factor for cardiovascular disease (CVD). TG levels are inversely correlated with high density lipoprotein cholesterol (HDL-C) levels, and their metabolism may be closely interrelated. Therefore, the TG/HDL-C ratio may be a relevant CVD risk factor. Our analysis of families in the Framingham Heart Study gave a genetic heritability estimate for log(TG) of 0.40 and for log(TG/HDL-C) of 0.49, demonstrating an important genetic component for both. A 10 cM genome-wide scan for log(TG) level and log(TG/HDL-C) was carried out for the largest 332 extended families of the Framingham Heart Study (1702 genotyped individuals). The highest multipoint variance component LOD scores obtained for both log(TG) and log(TG/HDL-C) were on chromosome 7 (at 155 cM), where the results for the two phenotypes were 1.8 and 2.5, respectively. The 7q32.3-qter region contains several candidate genes. Four other regions with multipoint LOD scores greater than one were identified on chromosome 3 [LOD score for log(TG/HDL-C) = 1.8 at 140 cM], chromosome 11 [LOD score for log(TG/HDL-C) = 1.1 at 125 cM], chromosome 16 [LOD score for log(TG) = 1.5 at 70 cM, LOD score for log(TG/HDL-C) = 1.1 at 75 cM] and chromosome 20 [LOD score for log(TG/HDL-C) = 1.7 at 35 cM, LOD score for log(TG) = 1.3 at 40 cM]. These results identify loci worthy of further study.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0964-6906
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pubmed:author |
pubmed-author:CupplesL ALA,
pubmed-author:DeStefanoA LAL,
pubmed-author:HarmonM DMD,
pubmed-author:HousmanD EDE,
pubmed-author:JoostOO,
pubmed-author:KeenJ DJD,
pubmed-author:MyersR HRH,
pubmed-author:OrdovasJ MJM,
pubmed-author:RAILG AGA,
pubmed-author:SchaeferE JEJ,
pubmed-author:ShearmanA MAM,
pubmed-author:WilsonP WPW
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1315-20
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10814713-Aged,
pubmed-meshheading:10814713-Aged, 80 and over,
pubmed-meshheading:10814713-Cardiovascular Diseases,
pubmed-meshheading:10814713-Cholesterol, HDL,
pubmed-meshheading:10814713-Chromosomes, Human, Pair 7,
pubmed-meshheading:10814713-Cohort Studies,
pubmed-meshheading:10814713-Female,
pubmed-meshheading:10814713-Genetic Linkage,
pubmed-meshheading:10814713-Genome, Human,
pubmed-meshheading:10814713-Humans,
pubmed-meshheading:10814713-Lod Score,
pubmed-meshheading:10814713-Male,
pubmed-meshheading:10814713-Middle Aged,
pubmed-meshheading:10814713-Phenotype,
pubmed-meshheading:10814713-Triglycerides
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pubmed:year |
2000
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pubmed:articleTitle |
Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study.
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pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, shearman@mit.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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