Source:http://linkedlifedata.com/resource/pubmed/id/10813384
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2000-7-27
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pubmed:abstractText |
Inhibition of factor Xa (FXa) may interrupt thrombus progression. This study compared the antithrombotic activity of a novel FXa inhibitor, ZK-807834 [MW, 527 D; Ki (human FXa), 0.11 nM], with recombinant tick anticoagulant peptide [rTAP; MW, 6,685 D; Ki, (human FXa) = 0.28 nM], and DX-9065a [MW 445 D, Ki (human FXa), 40 nM] in rabbits with arterial thrombosis induced by electrical vascular injury. ZK-807834 also was compared with low molecular weight heparin (LMWH; MW, 5,500 D) during venous thrombosis induced by placing a copper wire and threads in the vena cava. Inhibitors were administered as an i.v. bolus and 2-h infusion. Total dosages of ZK-807834, > or =0.7 micromol/kg (n = 18); rTAP, > or =1 micromol/kg (n = 18); or DX-9065a, > or =11 micromol/kg (n = 18) decreased the incidence of arterial thrombotic occlusion compared with control animals (p < 0.05). However, five of six animals given the lowest effective dosage of rTAP and four of six animals given DX-9065a bled from a surgical incision >5 min, but only two of six animals given ZK-807834 bled >5 min. Venous clot weights were reduced compared with controls for dosages of ZK-807834 > or =0.007 micromol/kg (n = 36) or LMWH > or =0.2 micromol/kg (n = 18). Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were unchanged from baseline at the minimally effective dose of ZK-807834, whereas aPTT was increased twofold at the effective dose of LMWH. Thus ZK-807834 may be useful to attenuate thrombosis at lower dosages and with less perturbation of systemic hemostasis compared with available agents.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amidines,
http://linkedlifedata.com/resource/pubmed/chemical/Anticoagulants,
http://linkedlifedata.com/resource/pubmed/chemical/Antithrombin III,
http://linkedlifedata.com/resource/pubmed/chemical/Arthropod Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DX 9065a,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Propionic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/ZK 807834,
http://linkedlifedata.com/resource/pubmed/chemical/tick anticoagulant peptide
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0160-2446
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
796-805
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10813384-Amidines,
pubmed-meshheading:10813384-Animals,
pubmed-meshheading:10813384-Anticoagulants,
pubmed-meshheading:10813384-Antithrombin III,
pubmed-meshheading:10813384-Arthropod Proteins,
pubmed-meshheading:10813384-Coronary Thrombosis,
pubmed-meshheading:10813384-Disease Models, Animal,
pubmed-meshheading:10813384-Female,
pubmed-meshheading:10813384-Male,
pubmed-meshheading:10813384-Naphthalenes,
pubmed-meshheading:10813384-Peptides,
pubmed-meshheading:10813384-Propionic Acids,
pubmed-meshheading:10813384-Pyridines,
pubmed-meshheading:10813384-Rabbits,
pubmed-meshheading:10813384-Species Specificity,
pubmed-meshheading:10813384-Venous Thrombosis
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pubmed:year |
2000
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pubmed:articleTitle |
Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits.
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pubmed:affiliation |
Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110, USA. dabendsc@imgate.wustl.edu
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pubmed:publicationType |
Journal Article,
Comparative Study
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