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pubmed-article:10813349pubmed:abstractTextThe pathophysiology of congenital diaphragmatic hernia (CDH) associated with lung hypoplasia and pulmonary hypertension is not understood fully. Endothelins (ETs) are the most potent vasoconstrictors that also act as promitogenic agents. They may play a role during pregnancy in leading to the condition found at birth and ongoing mortality in CDH. Therefore, the authors studied the effect of CGS 26303, a nonselective endothelin-converting enzyme and neutral endopeptidase inhibitor, in the rat model of CDH.lld:pubmed
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pubmed-article:10813349pubmed:articleTitleEffect of CGS 26303, an endothelin-converting enzyme-neutral endopeptidase inhibitor, on nitrofen-induced congenital diaphragmatic hernia in the rat.lld:pubmed
pubmed-article:10813349pubmed:affiliationAnaesthesiology and Neonatal Investigation Laboratory, Laval University Hospital Centre, CHUQ/CHUL, Sainte-Foy, Quebec, Canada.lld:pubmed
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