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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-7-14
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pubmed:abstractText |
The pathophysiology of congenital diaphragmatic hernia (CDH) associated with lung hypoplasia and pulmonary hypertension is not understood fully. Endothelins (ETs) are the most potent vasoconstrictors that also act as promitogenic agents. They may play a role during pregnancy in leading to the condition found at birth and ongoing mortality in CDH. Therefore, the authors studied the effect of CGS 26303, a nonselective endothelin-converting enzyme and neutral endopeptidase inhibitor, in the rat model of CDH.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-3468
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
780-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10813349-Animals,
pubmed-meshheading:10813349-Animals, Newborn,
pubmed-meshheading:10813349-Aspartic Acid Endopeptidases,
pubmed-meshheading:10813349-Body Weight,
pubmed-meshheading:10813349-Disease Models, Animal,
pubmed-meshheading:10813349-Female,
pubmed-meshheading:10813349-Hernia, Diaphragmatic,
pubmed-meshheading:10813349-Injections, Subcutaneous,
pubmed-meshheading:10813349-Linear Models,
pubmed-meshheading:10813349-Liver,
pubmed-meshheading:10813349-Lung,
pubmed-meshheading:10813349-Metalloendopeptidases,
pubmed-meshheading:10813349-Organ Size,
pubmed-meshheading:10813349-Phenyl Ethers,
pubmed-meshheading:10813349-Phosphonic Acids,
pubmed-meshheading:10813349-Pregnancy,
pubmed-meshheading:10813349-Proportional Hazards Models,
pubmed-meshheading:10813349-Protease Inhibitors,
pubmed-meshheading:10813349-Rats,
pubmed-meshheading:10813349-Reference Values,
pubmed-meshheading:10813349-Survival Analysis,
pubmed-meshheading:10813349-Tetrazoles
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pubmed:year |
2000
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pubmed:articleTitle |
Effect of CGS 26303, an endothelin-converting enzyme-neutral endopeptidase inhibitor, on nitrofen-induced congenital diaphragmatic hernia in the rat.
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pubmed:affiliation |
Anaesthesiology and Neonatal Investigation Laboratory, Laval University Hospital Centre, CHUQ/CHUL, Sainte-Foy, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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