Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2000-6-30
pubmed:abstractText
We have investigated the role of the ryanodine receptor in Drosophila development by using pharmacological and genetic approaches. We identified a P element insertion in the Drosophila ryanodine receptor gene, Ryanodine receptor 44F (Ryr), and used it to generate the hypomorphic allele Ryr(16). An examination of hypodermal, visceral, and circulatory muscle showed that, in each case, muscle contraction was impaired in Ryr(16) larvae. Treatment with the drug ryanodine, a highly specific modulator of ryanodine receptor channel activity, also inhibited muscle function, and, at high levels, completely blocked hypodermal muscle contraction. These results suggest that the ryanodine receptor is required for proper muscle function and may be essential for excitation-contraction coupling in larval body wall muscles. Nonmuscle roles of Ryr were also investigated. Ryanodine-sensitive Ca(2+) stores had previously been implicated in phototransduction; to address this, we generated Ryr(16) mutant clones in the adult eye and performed whole-cell, patch-clamp recordings on dissociated ommatidia. Our results do not support a role for Ryr in normal light responses.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-10225996, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-10359593, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-10508160, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-1338312, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-1961249, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-2422165, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-2476281, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-2550460, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-4999727, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-6027107, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-7479892, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-7515481, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-8276118, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-8306893, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-8404527, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-8568510, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-8578608, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-8637889, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-8874493, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9027311, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9208856, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9284301, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9384575, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9628868, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9671578, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9730981, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9790183, http://linkedlifedata.com/resource/pubmed/commentcorrection/10811919-9990044
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5942-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
The ryanodine receptor is essential for larval development in Drosophila melanogaster.
pubmed:affiliation
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94702, USA. kmcs@uclink5.berkeley.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't