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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
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pubmed:dateCreated |
2000-6-15
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pubmed:abstractText |
In in vitro studies, synergism and sequence-dependent effects were reported for the combination of topotecan and cisplatin. Recently, an oral formulation of topotecan became available. This phase I study was performed to assess the feasibility of the combination of oral topotecan and cisplatin, the pharmacokinetic interaction, and sequence-dependent effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0732-183X
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pubmed:author |
pubmed-author:BrouwerEE,
pubmed-author:DoyleEE,
pubmed-author:GelderblomHH,
pubmed-author:HearnSS,
pubmed-author:LoosW JWJ,
pubmed-author:MantelM AMA,
pubmed-author:PlantingA SAS,
pubmed-author:RossGG,
pubmed-author:SparreboomAA,
pubmed-author:VerweijJJ,
pubmed-author:de JongeM JMJ,
pubmed-author:van BeurdenVV,
pubmed-author:van der BurgM EME
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2104-15
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:10811676-Adult,
pubmed-meshheading:10811676-Aged,
pubmed-meshheading:10811676-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:10811676-Area Under Curve,
pubmed-meshheading:10811676-Cisplatin,
pubmed-meshheading:10811676-Cross-Over Studies,
pubmed-meshheading:10811676-Drug Administration Schedule,
pubmed-meshheading:10811676-Drug Interactions,
pubmed-meshheading:10811676-Feasibility Studies,
pubmed-meshheading:10811676-Female,
pubmed-meshheading:10811676-Humans,
pubmed-meshheading:10811676-Infusions, Intravenous,
pubmed-meshheading:10811676-Male,
pubmed-meshheading:10811676-Middle Aged,
pubmed-meshheading:10811676-Neoplasms,
pubmed-meshheading:10811676-Neutropenia,
pubmed-meshheading:10811676-Thrombocytopenia,
pubmed-meshheading:10811676-Topotecan
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pubmed:year |
2000
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pubmed:articleTitle |
Phase I pharmacologic study of oral topotecan and intravenous cisplatin: sequence-dependent hematologic side effects.
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pubmed:affiliation |
Department of Medical Oncology, Rotterdam Cancer Institute, and University Hospital Rotterdam, the Netherlands. jonge@onch.azr.nl
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Clinical Trial, Phase I
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