Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-8-31
pubmed:abstractText
Spoilage is a primary factor in the biocompatibility of soft contact lenses (SCL) within the lacrimal fluid. Tears are a complex mixture of proteins, lipids, natural surfactants and salts. The spoilation process is due to a contribution of all these components and of the nature of SCL materials themselves. The aim of this study was to set up methods to observe and quantify lacrimal deposits and to select efficient surfactants for preventing protein deposits. The present study was performed on PMMA-NVP SCL. The behaviour of SCL in presence of tears was studied by means of an in vitro artificial tear model consisting of the main tears components and quantified by a colorimetric technique (BCA) performed directly on the lenses. The nature of the deposit was observed directly by atomic force microscopy (AFM) in a liquid medium showing the same adsorption trend noticed in the quantitative results and identifying specific adsorption sites. The assessment of surfactant adsorption was performed using Maron's method, as a mean to evaluate the affinity of surfactant to the surface, while the action of selected surfactants on pre-treated SCL was assessed using the BCA method. Promising results were obtained with these two different methods which can be used easily for the pre-selection of surfactants for further cleaning solution formulation studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Buffers, http://linkedlifedata.com/resource/pubmed/chemical/Glucosides, http://linkedlifedata.com/resource/pubmed/chemical/Lipids, http://linkedlifedata.com/resource/pubmed/chemical/Methylmethacrylates, http://linkedlifedata.com/resource/pubmed/chemical/Ophthalmic Solutions, http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols, http://linkedlifedata.com/resource/pubmed/chemical/Polymers, http://linkedlifedata.com/resource/pubmed/chemical/Polysorbates, http://linkedlifedata.com/resource/pubmed/chemical/Povidone, http://linkedlifedata.com/resource/pubmed/chemical/Propylene Glycols, http://linkedlifedata.com/resource/pubmed/chemical/Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Surface-Active Agents, http://linkedlifedata.com/resource/pubmed/chemical/Thioglucosides, http://linkedlifedata.com/resource/pubmed/chemical/n-octyl-beta-D-thioglucopyranoside, http://linkedlifedata.com/resource/pubmed/chemical/octyl-beta-D-glucoside, http://linkedlifedata.com/resource/pubmed/chemical/poly(methylmethacrylate-N-vinylpyrro..., http://linkedlifedata.com/resource/pubmed/chemical/polypropylene glycol, http://linkedlifedata.com/resource/pubmed/chemical/polysorbate 40
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1197-205
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10811301-Adsorption, pubmed-meshheading:10811301-Biofilms, pubmed-meshheading:10811301-Buffers, pubmed-meshheading:10811301-Colorimetry, pubmed-meshheading:10811301-Contact Lenses, Hydrophilic, pubmed-meshheading:10811301-Drug Evaluation, pubmed-meshheading:10811301-Drug Stability, pubmed-meshheading:10811301-Glucosides, pubmed-meshheading:10811301-Lipids, pubmed-meshheading:10811301-Methylmethacrylates, pubmed-meshheading:10811301-Microscopy, Atomic Force, pubmed-meshheading:10811301-Ophthalmic Solutions, pubmed-meshheading:10811301-Polyethylene Glycols, pubmed-meshheading:10811301-Polymers, pubmed-meshheading:10811301-Polysorbates, pubmed-meshheading:10811301-Povidone, pubmed-meshheading:10811301-Propylene Glycols, pubmed-meshheading:10811301-Proteins, pubmed-meshheading:10811301-Reproducibility of Results, pubmed-meshheading:10811301-Surface Properties, pubmed-meshheading:10811301-Surface-Active Agents, pubmed-meshheading:10811301-Thioglucosides, pubmed-meshheading:10811301-Wettability
pubmed:year
2000
pubmed:articleTitle
Artificial tear adsorption on soft contact lenses: methods to test surfactant efficacy.
pubmed:affiliation
Université Claude Bernard, Villeurbanne, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't