| pubmed-article:10809963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10809963 | lifeskim:mentions | umls-concept:C1706513 | lld:lifeskim |
| pubmed-article:10809963 | lifeskim:mentions | umls-concept:C0376618 | lld:lifeskim |
| pubmed-article:10809963 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10809963 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:10809963 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:10809963 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10809963 | pubmed:dateCreated | 2000-5-31 | lld:pubmed |
| pubmed-article:10809963 | pubmed:abstractText | By targeted disruption of the MIF gene, we have established a mouse strain deficient in macrophage (Mphi) migration inhibitory factor (MIF). Despite previous reports indicating an essential role of MIF in endotoxaemia, an injection of lipopolysaccharide (LPS) into the MIF-deficient mice (maintained under specific pathogen-free conditions) caused shock. No significant difference was detected between the MIF-deficient mutant and normal mice in susceptibility to LPS for endotoxaemia or tumour necrosis factor-alpha (TNF-alpha) formation upon LPS injection. Peritoneal Mphi from the two strains produced TNF-alpha in response to LPS with similar dose responses. Dexamethasone suppressed the LPS-induced TNF-alpha response of Mphi, but no difference was detected between the Mphi from the two strains. These results suggest that endogenous MIF has no significant effect on the LPS-induced TNF-alpha production and no effect on suppression of the response by glucocorticoids. Thus, MIF is not crucial for LPS-induced immune responses leading to shock. | lld:pubmed |
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| pubmed-article:10809963 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10809963 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10809963 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10809963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10809963 | pubmed:month | May | lld:pubmed |
| pubmed-article:10809963 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:NakayamaTT | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:TaniguchiMM | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:AkahoriHH | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:OsawaMM | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:AkasakaTT | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:MikayamaTT | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:KosekiHH | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:HonmaNN | lld:pubmed |
| pubmed-article:10809963 | pubmed:author | pubmed-author:SerizawaII | lld:pubmed |
| pubmed-article:10809963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10809963 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:10809963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10809963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10809963 | pubmed:pagination | 84-90 | lld:pubmed |
| pubmed-article:10809963 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:10809963 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10809963 | pubmed:articleTitle | Deficiency of the macrophage migration inhibitory factor gene has no significant effect on endotoxaemia. | lld:pubmed |
| pubmed-article:10809963 | pubmed:affiliation | Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd, Gunma, Japan. | lld:pubmed |
| pubmed-article:10809963 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:17319 | entrezgene:pubmed | pubmed-article:10809963 | lld:entrezgene |
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