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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-5-31
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pubmed:abstractText |
By targeted disruption of the MIF gene, we have established a mouse strain deficient in macrophage (Mphi) migration inhibitory factor (MIF). Despite previous reports indicating an essential role of MIF in endotoxaemia, an injection of lipopolysaccharide (LPS) into the MIF-deficient mice (maintained under specific pathogen-free conditions) caused shock. No significant difference was detected between the MIF-deficient mutant and normal mice in susceptibility to LPS for endotoxaemia or tumour necrosis factor-alpha (TNF-alpha) formation upon LPS injection. Peritoneal Mphi from the two strains produced TNF-alpha in response to LPS with similar dose responses. Dexamethasone suppressed the LPS-induced TNF-alpha response of Mphi, but no difference was detected between the Mphi from the two strains. These results suggest that endogenous MIF has no significant effect on the LPS-induced TNF-alpha production and no effect on suppression of the response by glucocorticoids. Thus, MIF is not crucial for LPS-induced immune responses leading to shock.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-10092824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-1506688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-1508193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-1716205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-2007851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-2212948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-2552447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-2783705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-2784476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-2809510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-3017195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-3317066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-3356468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-3721620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-3895437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-4564107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-5229858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-5444647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-5938421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-7558021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-7659164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-7706726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-7722463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-7947826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8087451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8195715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8234256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8378314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8393046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8413654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8458415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8900542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-8924353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9058823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9144228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9182689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9440119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9637476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9653033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9725234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10809963-9892616
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10809963-Animals,
pubmed-meshheading:10809963-Anti-Inflammatory Agents,
pubmed-meshheading:10809963-Dexamethasone,
pubmed-meshheading:10809963-Endotoxemia,
pubmed-meshheading:10809963-Fertility,
pubmed-meshheading:10809963-Lipopolysaccharides,
pubmed-meshheading:10809963-Macrophage Activation,
pubmed-meshheading:10809963-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:10809963-Macrophages, Peritoneal,
pubmed-meshheading:10809963-Mice,
pubmed-meshheading:10809963-Mice, Knockout,
pubmed-meshheading:10809963-Shock, Septic,
pubmed-meshheading:10809963-Survival Rate,
pubmed-meshheading:10809963-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
Deficiency of the macrophage migration inhibitory factor gene has no significant effect on endotoxaemia.
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pubmed:affiliation |
Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd, Gunma, Japan.
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pubmed:publicationType |
Journal Article
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