Linked Life Data

10809372

Source:http://linkedlifedata.com/resource/pubmed/id/10809372

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-7-12
pubmed:abstractText
The purpose of this study was to characterize ligands for galectins, natural galactoside-binding immunoglobulin G subfractions and sarcolectin and also the expression of calcyclin in various benign and malignant thyroid lesions. The extent of the binding of eight glycochemical probes was quantitatively assessed using computer-assisted microscopy on 76 thyroid lesions including 10 not-otherwise-specified multinodular goiters (S_MNG), 11 multinodular goiters with adenomatous hyperplasia (AH_MNG), 8 normomacrovesicular (NM_ADE) and 12 microvesicular (MIC_ADE) adenomas, and 9 papillary (P_CAR), 10 follicular variants of papillary (FvarP_CAR), 7 follicular (F_CAR) and 9 anaplastic (A_CAR) carcinomas. The 8 histochemical probes included 5 animal lectins (including galectins and sarcolectin), 1 polyclonal antibody (raised against calcyclin) and 2 immunoglobulin G subfractions from human serum with selectivity to alpha- and beta-galactosyl residues. The results show that multinodular goiters with adenomatous hyperplasia exhibited histochemical characteristics intermediate to those of normal multinodular goiters and microvesicular adenomas. Normomacrovesicular adenomas behaved very distinctly from microvesicular ones. Microvesicular adenomas were more closely related to differentiated thyroid carcinomas than any other type of benign thyroid lesions of epithelial origin. Papillary and follicular carcinomas seemed to represent the two extremes of the same biological entity with the follicular variant of the papillary carcinoma serving as a biological link between these two extremes. Anaplastic carcinomas behaved in a significantly different manner when compared to the differentiated forms of thyroid carcinomas. The results suggest that the patterns of expression of the glycoconjugates investigated in the present study may constitute useful tools for characterizing lesions in the human thyroid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0213-3911
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
503-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10809372-Adenocarcinoma, pubmed-meshheading:10809372-Adolescent, pubmed-meshheading:10809372-Adult, pubmed-meshheading:10809372-Aged, pubmed-meshheading:10809372-Cell Cycle Proteins, pubmed-meshheading:10809372-Chemical Fractionation, pubmed-meshheading:10809372-Female, pubmed-meshheading:10809372-Galactosides, pubmed-meshheading:10809372-Galectins, pubmed-meshheading:10809372-Goiter, Nodular, pubmed-meshheading:10809372-Hemagglutinins, pubmed-meshheading:10809372-Humans, pubmed-meshheading:10809372-Immunoglobulin G, pubmed-meshheading:10809372-Lectins, pubmed-meshheading:10809372-Ligands, pubmed-meshheading:10809372-Male, pubmed-meshheading:10809372-Middle Aged, pubmed-meshheading:10809372-S100 Proteins, pubmed-meshheading:10809372-Thyroid Gland, pubmed-meshheading:10809372-Thyroid Neoplasms
pubmed:year
2000
pubmed:articleTitle
Characterization of ligands for galectins, natural galactoside-binding immunoglobulin G subfractions and sarcolectin and also of the expression of calcyclin in thyroid lesions.
pubmed:affiliation
Department of Pathology, Erasmus University Hospital, Brussels, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't