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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-5-31
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pubmed:abstractText |
Effects of thyroid hormone deficiency on 5-HT1A receptors, 5-HT2A receptors and serotonin transporter in the brain were studied in thyroidectomised Wistar rats receiving an iodine-free diet and receiving 15 micrograms/kg of thyroxine for 21 days. Binding of 3H-8-OH-DPAT to 5-HT1A receptors and 3H-cytalopram to serotonin transporter were unchanged in hypothyroid rats as compared to the control. 3H-ketanserin binding to 5-HT2A receptors was significantly decreased in the frontal cortex in hypothyroid rats. The cortical 3H-ketanserin binding in thyroidectomised rats was normalised after thyroxine replacement. The data suggest that the decrease in the cortical 5-HT2A receptors is the main consequence of impairing effect of hypothyroidism on serotonin neurotransmission.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0869-8139
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
312-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10808528-Animals,
pubmed-meshheading:10808528-Brain,
pubmed-meshheading:10808528-Carrier Proteins,
pubmed-meshheading:10808528-Cerebral Cortex,
pubmed-meshheading:10808528-Hippocampus,
pubmed-meshheading:10808528-Hypothyroidism,
pubmed-meshheading:10808528-Male,
pubmed-meshheading:10808528-Membrane Glycoproteins,
pubmed-meshheading:10808528-Membrane Transport Proteins,
pubmed-meshheading:10808528-Mesencephalon,
pubmed-meshheading:10808528-Nerve Tissue Proteins,
pubmed-meshheading:10808528-Radioligand Assay,
pubmed-meshheading:10808528-Rats,
pubmed-meshheading:10808528-Rats, Wistar,
pubmed-meshheading:10808528-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:10808528-Receptors, Serotonin,
pubmed-meshheading:10808528-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:10808528-Serotonin,
pubmed-meshheading:10808528-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:10808528-Synapses
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pubmed:year |
2000
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pubmed:articleTitle |
[Effect of hypothyroidism on 5-HT1A-, 5-HT2A-receptors and serotonin transporter in the rat brain].
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pubmed:affiliation |
Institute of Cytology and Genetics, Siberian Branch of the Russian Acad. Sci., Novosibirsk, Russia.
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pubmed:publicationType |
Journal Article,
English Abstract
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