Linked Life Data

10806322

Source:http://linkedlifedata.com/resource/pubmed/id/10806322

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-8-1
pubmed:abstractText
We determined whether estrogen regulates the expression of arginine-vasopressin (AVP) receptor mRNA in the preoptic area (POA) of female rats. By reverse transcription-polymerase chain reaction (PCR), we found that all three types of the AVP receptor mRNA, V1a, V1b and V2, were expressed in the POA, though the amount of PCR products was apparently different among them. In situ hybridization indicated that AVP V1a receptor mRNA was densely expressed in the POA, especially in the anteroventral periventricular nucleus of the POA; in contrast, AVP V1b and V2 receptor mRNAs were not abundant in this area. Finally, we demonstrated by Northern blot that estrogen significantly increased the expression of AVP V1a receptor mRNA in the POA of young ovariectomized rats. However, this regulation by estrogen was lost in middle-aged rats, indicating an age-related impairment in the regulation of AVP V1a receptor mRNA by estrogen in the POA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Estrogen increases arginine-vasopressin V1a receptor mRNA in the preoptic area of young but not of middle-aged female rats.
pubmed:affiliation
Department of Physiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. toshiya@med.yokohama-cu.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't