Linked Life Data

10806139

Source:http://linkedlifedata.com/resource/pubmed/id/10806139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-6-21
pubmed:abstractText
Previous studies have shown that the regular administration of short acting beta-agonists can be associated with adverse effects on airway caliber and bronchial hyperresponsiveness (BHR) and that this may occur through a proinflammatory mechanism. The aim was to explore possible adverse effects of high-dose beta-agonist therapy and to assess any adverse interaction with corticosteroids. We undertook a randomized, crossover study to investigate the effects of 6 wk of treatment with regular terbutaline (1 mg four times a day), regular budesonide (400 microg twice a day), combined treatment, and placebo in subjects with mild to moderate asthma. Major endpoints were PD(15) saline, PD(20) methacholine, and induced sputum differential cell counts. Thirty-four subjects were randomized and 28 completed the study. PD(15) saline decreased on terbutaline alone compared with placebo treatment and on combined treatment compared with budesonide alone (mean fold decrease of 0.57 [95% CI = 0.36, 0.90] and 0.65 [95% CI = 0.43, 0.97], respectively). PD(20) methacholine was not affected by the use of terbutaline either alone or in combination with budesonide. The percentage of eosinophils in induced sputum increased during terbutaline treatment alone compared with placebo (median 8.3% versus 4.4%, p = 0.049). The addition of terbutaline to budesonide did not affect the percentage of eosinophils compared with budesonide treatment alone. These findings support the hypothesis that short-acting beta-agonists have a permissive effect on airway inflammation and that when used in high dose there may be an unfavorable interaction with inhaled corticosteroids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1459-64
pubmed:dateRevised
2009-3-25
pubmed:meshHeading
pubmed-meshheading:10806139-Administration, Topical, pubmed-meshheading:10806139-Adolescent, pubmed-meshheading:10806139-Adrenergic beta-Agonists, pubmed-meshheading:10806139-Adult, pubmed-meshheading:10806139-Anti-Inflammatory Agents, pubmed-meshheading:10806139-Asthma, pubmed-meshheading:10806139-Bronchial Hyperreactivity, pubmed-meshheading:10806139-Bronchial Provocation Tests, pubmed-meshheading:10806139-Bronchodilator Agents, pubmed-meshheading:10806139-Budesonide, pubmed-meshheading:10806139-Cell Count, pubmed-meshheading:10806139-Cross-Over Studies, pubmed-meshheading:10806139-Double-Blind Method, pubmed-meshheading:10806139-Drug Interactions, pubmed-meshheading:10806139-Drug Therapy, Combination, pubmed-meshheading:10806139-Female, pubmed-meshheading:10806139-Forced Expiratory Volume, pubmed-meshheading:10806139-Glucocorticoids, pubmed-meshheading:10806139-Humans, pubmed-meshheading:10806139-Male, pubmed-meshheading:10806139-Methacholine Chloride, pubmed-meshheading:10806139-Middle Aged, pubmed-meshheading:10806139-Peak Expiratory Flow Rate, pubmed-meshheading:10806139-Sodium Chloride, pubmed-meshheading:10806139-Sputum, pubmed-meshheading:10806139-Terbutaline
pubmed:year
2000
pubmed:articleTitle
Effects of terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma.
pubmed:affiliation
Canterbury and Otago Respiratory Research Groups, Christchurch and Dunedin Schools of Medicine, University of Otago, Christchurch, New Zealand.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't