Source:http://linkedlifedata.com/resource/pubmed/id/10803852
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0019630,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0054315,
umls-concept:C0086418,
umls-concept:C0205147,
umls-concept:C0205284,
umls-concept:C0456387,
umls-concept:C1334043,
umls-concept:C1412849,
umls-concept:C1517488,
umls-concept:C1708726,
umls-concept:C1882417,
umls-concept:C2697616
|
| pubmed:issue |
4-5
|
| pubmed:dateCreated |
2000-5-25
|
| pubmed:databankReference | |
| pubmed:abstractText |
Comparison of human and mouse genomic sequence at the border of the major histocompatibility complex (MHC) class II and class III regions revealed a locus encoding six exons with homology to the butyrophilin gene family and the location of a previously described gene, testis-specific basic protein (TSBP). We named the new locus BTL-II, for butyrophilin-like MHC class II associated. The six discernable exons of the BTL-II locus encode a small hydrophobic amino acid sequence (which may be a signal peptide), two immunoglobulin domains, a small 7-amino acid, heptad repeat-like exon, and a further two immunoglobulin domains. In mouse, an additional butyrophilin-like gene (NG10) is situated adjacent to BTL-II. Expression studies of the BTL-II locus in mouse showed that it is expressed in a range of gut tissues. We demonstrate that like many other genes from the MHC, BTL-II is polymorphic in a selection of diverse HLA haplotypes. In the light of the newly discovered locus, we revisit and discuss the possible origin of the butyrophilin gene family.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0093-7711
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
373-82
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10803852-Amino Acid Sequence,
pubmed-meshheading:10803852-Animals,
pubmed-meshheading:10803852-Cloning, Molecular,
pubmed-meshheading:10803852-Exons,
pubmed-meshheading:10803852-Genes, MHC Class II,
pubmed-meshheading:10803852-Humans,
pubmed-meshheading:10803852-Inflammatory Bowel Diseases,
pubmed-meshheading:10803852-Intestines,
pubmed-meshheading:10803852-Major Histocompatibility Complex,
pubmed-meshheading:10803852-Membrane Glycoproteins,
pubmed-meshheading:10803852-Mice,
pubmed-meshheading:10803852-Molecular Sequence Data,
pubmed-meshheading:10803852-Multigene Family,
pubmed-meshheading:10803852-Phylogeny,
pubmed-meshheading:10803852-Polymorphism, Genetic,
pubmed-meshheading:10803852-Sequence Analysis, DNA,
pubmed-meshheading:10803852-Sequence Homology, Amino Acid,
pubmed-meshheading:10803852-Tissue Distribution
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse.
|
| pubmed:affiliation |
Sanger Centre, Wellcome Trust Genome Campus, Cambridge, UK.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|