Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2000-6-14
pubmed:abstractText
In two papers in Cell researchers of the University Medical Center St. Radboud in Nijmegen (in collaboration with Utrecht and US researchers) have published the results of studies dealing with dendritic cells and their role in the pathogenesis of HIV-1 infection. First, they identified a dendritic cell receptor, DC-SIGN, that mediates adhesion with T cells. Second, they described another property of DC-SIGN, i.e. binding to the HIV-1 envelope protein gp120. Through this binding dendritic cells can transport HIV-1 to the CD4+ cells in lymphoid organs. Interestingly, it appeared that dendritic cells themselves are not infected by HIV-1, but only act as carriers for HIV-1. These findings may have important consequences for the design of new options for intervention in HIV-1 infection.
pubmed:language
dut
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-2162
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
786-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
[Dendritic cells as carriers of human immunodeficiency virus (HIV)].
pubmed:affiliation
Afd. Interne Geneeskunde, onderafd. Infectieziekten & Aids, Universitair Medisch Centrum Utrecht. j.c.c.borleffs@digd.azu.nl
pubmed:publicationType
Journal Article, English Abstract, Review