|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1975-10-11
|
|
pubmed:abstractText |
Spleen cells cultured with syngeneic trinitrophenyl (TNP)-modified stimulator cells display a cytotoxic effect against syngeneic TNP-modified targets, but not against modified targets from unrelated H-2 haplotypes. Targets that share the K and I region of the H-2 complex with the stimulator (or effector) cell are lysed to the same extent as the specific targets, while targets that share the I region only are not. When only the D region is shared, a weak cytotoxic effect is observed. Therefore, the stimulator (or effector) and target cell must share the K or D but not the I region of the H-2 complex in order for optimal cytotoxicity to occur. Spleen cells sensitized to irradiated TNP-modified H-2-allogeneic cells are cytotoxic to these specific cells. Coculture of F1 hybrid cells with irradiated TNP-modified parental cells result in a cytotoxic effect against only those specific parental cells and not TNP-modified cells from the other parent. The cytotoxic effect of the F1 effector cells in the cell-mediated lympholysis test is blocked by the addition of unlabeled TNP-modified targets that are H-2 syngeneic with the sensitizing parental strain, but not H-2 syngeneic with the other parental strain. These data demonstrate that the specificity of the effector cell in this syngeneic cytotoxicity system is directed against altered self H-2-controlled-gene products, rather than a requirement for sharing of histocompatibility genes between effector and target cell in order for lysis to occur. The role of H-2 antigens in determining the sensitivity of a target cell to T-cell-mediated lysis is discussed.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-1078719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-1089744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-1090698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-13233805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-14169112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4108876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4121834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4122709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4133807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4202329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4267208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4269560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4277395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4331946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4343540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4540590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4540806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4547153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4547543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4841060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-4882575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1079848-5349009
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
142
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
403-18
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1079848-Animals,
pubmed-meshheading:1079848-Cesium Radioisotopes,
pubmed-meshheading:1079848-Chromium Radioisotopes,
pubmed-meshheading:1079848-Chromosome Mapping,
pubmed-meshheading:1079848-Concanavalin A,
pubmed-meshheading:1079848-Cross Reactions,
pubmed-meshheading:1079848-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:1079848-Gamma Rays,
pubmed-meshheading:1079848-Histocompatibility Antigens,
pubmed-meshheading:1079848-Hybridization, Genetic,
pubmed-meshheading:1079848-Lymphocytes,
pubmed-meshheading:1079848-Mice,
pubmed-meshheading:1079848-Mice, Inbred Strains,
pubmed-meshheading:1079848-Neoplasm Transplantation,
pubmed-meshheading:1079848-Neoplasms,
pubmed-meshheading:1079848-Nitrobenzenes,
pubmed-meshheading:1079848-Radiation Effects,
pubmed-meshheading:1079848-Spleen,
pubmed-meshheading:1079848-T-Lymphocytes,
pubmed-meshheading:1079848-Trinitrobenzenesulfonic Acid
|
|
pubmed:year |
1975
|
|
pubmed:articleTitle |
On the role of the H-2 histocompatibility complex in determining the specificity of cytotoxic effector cells sensitized against syngeneic trinitrophenyl-modified targets.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
