Source:http://linkedlifedata.com/resource/pubmed/id/10797139
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2000-6-23
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pubmed:abstractText |
The goal of this study was to determine whether the stress of forced exercise would result in injury to the myocardium. Male rats with 8% of body weight attached to the tail were forced to swim 3.5 h (3.5S), forced to swim 5 h (5S), or pretrained for 8 days and then forced to swim 5 h (T5S). Rats were killed immediately after they swam (0 h PS) and at 3 h (3 h PS), 24 h (24 h PS), and 48 h after they swam (48 h PS). Tissue homogenates of the left ventricle were analyzed by Western blot analysis for cardiac troponin T (cTnT). Serum cTnT was quantified by immunoassay. Results indicated that, in the 3.5S, 5S, and T5S groups, serum cTnT was significantly (P < 0.01) increased at 0 and 3 h PS. The 5S group demonstrated a greater increase in serum cTnT than the 3.5S group (P < 0.01) and the T5S group (P < 0.01) at 0 h PS. Western blot analysis indicated significant decreases (P < 0. 01) in myocardial cTnT in the 5S group only at 0 h PS (P < 0.01) and 3 h PS (P < 0.05). Histological evidence of localized myocyte damage demonstrated by interstitial inflammatory infiltrates consisting of neutrophils, lymphocytes, and histiocytes, as well as vesicular nuclei-enlarged chromatin patterns, was observed in left ventricle specimens from the 5S group at 24 and 48 h PS. Our findings demonstrate that stressful, forced exercise induces alterations in myocardial cTnT and that training before exercise attenuates the exercise-induced heart damage.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
8750-7587
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1749-55
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10797139-Animals,
pubmed-meshheading:10797139-Male,
pubmed-meshheading:10797139-Motor Activity,
pubmed-meshheading:10797139-Myocardium,
pubmed-meshheading:10797139-Physical Endurance,
pubmed-meshheading:10797139-Rats,
pubmed-meshheading:10797139-Rats, Sprague-Dawley,
pubmed-meshheading:10797139-Stress, Physiological,
pubmed-meshheading:10797139-Time Factors,
pubmed-meshheading:10797139-Troponin T
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pubmed:year |
2000
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pubmed:articleTitle |
Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise.
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pubmed:affiliation |
Division of Kinesiology, School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis 55455, Minnesota, USA.
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pubmed:publicationType |
Journal Article
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