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pubmed-article:10797009pubmed:abstractTextLight signals perceived by the phytochrome family of sensory photoreceptors are transduced to photoresponsive genes by an unknown mechanism. Here, we show that the basic helix-loop-helix transcription factor PIF3 binds specifically to a G-box DNA-sequence motif present in various light-regulated gene promoters, and that phytochrome B binds reversibly to G-box-bound PIF3 specifically upon light-triggered conversion of the photoreceptor to its biologically active conformer. We suggest that the phytochromes may function as integral light-switchable components of transcriptional regulator complexes, permitting continuous and immediate sensing of changes in this environmental signal directly at target gene promoters.lld:pubmed
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pubmed-article:10797009pubmed:articleTitleDirect targeting of light signals to a promoter element-bound transcription factor.lld:pubmed
pubmed-article:10797009pubmed:affiliationDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.lld:pubmed
pubmed-article:10797009pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10797009pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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