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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5467
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pubmed:dateCreated |
2000-5-11
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pubmed:abstractText |
Light signals perceived by the phytochrome family of sensory photoreceptors are transduced to photoresponsive genes by an unknown mechanism. Here, we show that the basic helix-loop-helix transcription factor PIF3 binds specifically to a G-box DNA-sequence motif present in various light-regulated gene promoters, and that phytochrome B binds reversibly to G-box-bound PIF3 specifically upon light-triggered conversion of the photoreceptor to its biologically active conformer. We suggest that the phytochromes may function as integral light-switchable components of transcriptional regulator complexes, permitting continuous and immediate sensing of changes in this environmental signal directly at target gene promoters.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/CCA1 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Plant,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LHY protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/PHYB protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/PIF3 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Photosynthetic Reaction Center...,
http://linkedlifedata.com/resource/pubmed/chemical/Phytochrome,
http://linkedlifedata.com/resource/pubmed/chemical/Phytochrome B,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SPA1 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
859-63
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10797009-Arabidopsis,
pubmed-meshheading:10797009-Arabidopsis Proteins,
pubmed-meshheading:10797009-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:10797009-Cell Cycle Proteins,
pubmed-meshheading:10797009-DNA, Plant,
pubmed-meshheading:10797009-DNA-Binding Proteins,
pubmed-meshheading:10797009-Gene Expression Profiling,
pubmed-meshheading:10797009-Gene Expression Regulation, Plant,
pubmed-meshheading:10797009-Genes, Plant,
pubmed-meshheading:10797009-Helix-Loop-Helix Motifs,
pubmed-meshheading:10797009-Light,
pubmed-meshheading:10797009-Models, Genetic,
pubmed-meshheading:10797009-Oligodeoxyribonucleotides,
pubmed-meshheading:10797009-Photoreceptor Cells,
pubmed-meshheading:10797009-Photosynthetic Reaction Center Complex Proteins,
pubmed-meshheading:10797009-Phytochrome,
pubmed-meshheading:10797009-Phytochrome B,
pubmed-meshheading:10797009-Plant Proteins,
pubmed-meshheading:10797009-Promoter Regions, Genetic,
pubmed-meshheading:10797009-Recombinant Fusion Proteins,
pubmed-meshheading:10797009-Signal Transduction,
pubmed-meshheading:10797009-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Direct targeting of light signals to a promoter element-bound transcription factor.
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pubmed:affiliation |
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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