Linked Life Data

10795916

Source:http://linkedlifedata.com/resource/pubmed/id/10795916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2000-6-27
pubmed:abstractText
A possible role for vasopressin and oxytocin in the physiology of the supraoptic nucleus was investigated using nystatin-perforated patch recording in acute brain slices from the rat containing the supraoptic nucleus. We observed that exogenously applied oxytocin reduced glutamate-mediated synaptic transmission by acting at a presynaptic oxytocin receptor. Endogenous oxytocin, released either by afferent excitation (tetanus) or by postsynaptic depolarization of the recorded magnocellular neurone caused a similar reduction of excitatory input and this could be blocked with an oxytocin antagonist. Thus endogenous oxytocin, released from magnocellular dendrites, acts as a retrograde transmitter to reduce afferent excitation. We discuss the possible significance of these results in terms of the physiological role of oxytocin in the intact animal and suggest possible avenues for further experimentation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0958-0670
pubmed:author
pubmed:issnType
Print
pubmed:volume
85 Spec No
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139S-143S
pubmed:dateRevised
2008-8-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Neurohypophysial peptides as retrograde transmitters in the supraoptic nucleus of the rat.
pubmed:affiliation
Department of Physiology and Biophysics, University of Calgary, Alberta, Canada. pittman@ucalgary.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't