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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1395
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pubmed:dateCreated |
2000-6-28
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pubmed:abstractText |
The cellular interactions involved in maintaining CD4+ T-cell memory have hitherto not been identified. In this report, we have investigated the role played by B cells in this process. We show that that long-lasting helper T-cell memory depends on the presence of B cells, but that direct antigen presentation by B cells is not required. These findings provide new insights into the mechanisms which underlie helper T-cell memory. They also suggest that the efficacy of future vaccines will depend critically on the inclusion of B- as well as T-cell epitopes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-1545868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-1834764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-2025614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-2185332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-2191683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-2832312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-3089914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-3257233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-3257234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-3263573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-401512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-4125287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-6162778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-7516038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-7516039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-7516404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-7561694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-7600301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-7884853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8195718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8270876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8293465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8454847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8524396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8600537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8642325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8642326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8658169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8816401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-8934523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-9016551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-9607920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794053-9620680
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0962-8436
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
355
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
351-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10794053-Animals,
pubmed-meshheading:10794053-Antigen-Presenting Cells,
pubmed-meshheading:10794053-B-Lymphocytes,
pubmed-meshheading:10794053-Female,
pubmed-meshheading:10794053-H-2 Antigens,
pubmed-meshheading:10794053-Hemocyanin,
pubmed-meshheading:10794053-Immunologic Memory,
pubmed-meshheading:10794053-Male,
pubmed-meshheading:10794053-Mice,
pubmed-meshheading:10794053-Mice, Inbred C57BL,
pubmed-meshheading:10794053-Mice, SCID,
pubmed-meshheading:10794053-T-Lymphocytes, Helper-Inducer
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pubmed:year |
2000
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pubmed:articleTitle |
Role of B cells in maintaining helper T-cell memory.
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pubmed:affiliation |
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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