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pubmed-article:10793189pubmed:abstractTextNeuromodulators which influence the operation of neural networks act as a rule via several cellular and synaptic mechanisms. Activation of GABA(B)-receptors in the lamprey spinal cord reduce both calcium currents and the peak amplitude of the post-spike afterhyperpolarization (AHP). Activation of GABA(B)-receptors reduce the segmental alternation rate and modifies the intersegmental coordination when the spinal locomotor circuits are activated by NMDA. Using physiological experiments we find that a reduced AHP is not sufficient to account for the observed reduction of the burst rate. Computer simulations revealed that either a reduced AHP or calcium current could alter the phase coordination between the segments similar to earlier experiments.lld:pubmed
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pubmed-article:10793189pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10793189pubmed:articleTitleGABA(B)-ergic modulation of burst rate and intersegmental coordination in lamprey: experiments and simulations.lld:pubmed
pubmed-article:10793189pubmed:affiliationDepartment of Neuroscience, Karolinska Institutet, S-171 77, Stockholm, Sweden. jespert@nada.kth.selld:pubmed
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