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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-8-11
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pubmed:abstractText |
Neuromodulators which influence the operation of neural networks act as a rule via several cellular and synaptic mechanisms. Activation of GABA(B)-receptors in the lamprey spinal cord reduce both calcium currents and the peak amplitude of the post-spike afterhyperpolarization (AHP). Activation of GABA(B)-receptors reduce the segmental alternation rate and modifies the intersegmental coordination when the spinal locomotor circuits are activated by NMDA. Using physiological experiments we find that a reduced AHP is not sufficient to account for the observed reduction of the burst rate. Computer simulations revealed that either a reduced AHP or calcium current could alter the phase coordination between the segments similar to earlier experiments.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Baclofen,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
864
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10793189-Action Potentials,
pubmed-meshheading:10793189-Animals,
pubmed-meshheading:10793189-Baclofen,
pubmed-meshheading:10793189-Calcium Channels,
pubmed-meshheading:10793189-Dose-Response Relationship, Drug,
pubmed-meshheading:10793189-Excitatory Amino Acid Agonists,
pubmed-meshheading:10793189-GABA Agonists,
pubmed-meshheading:10793189-Lampreys,
pubmed-meshheading:10793189-Models, Neurological,
pubmed-meshheading:10793189-N-Methylaspartate,
pubmed-meshheading:10793189-Nerve Net,
pubmed-meshheading:10793189-Neural Pathways,
pubmed-meshheading:10793189-Neurons,
pubmed-meshheading:10793189-Potassium Channels,
pubmed-meshheading:10793189-Receptors, GABA-B,
pubmed-meshheading:10793189-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:10793189-Spinal Cord,
pubmed-meshheading:10793189-Time Factors,
pubmed-meshheading:10793189-gamma-Aminobutyric Acid
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pubmed:year |
2000
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pubmed:articleTitle |
GABA(B)-ergic modulation of burst rate and intersegmental coordination in lamprey: experiments and simulations.
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pubmed:affiliation |
Department of Neuroscience, Karolinska Institutet, S-171 77, Stockholm, Sweden. jespert@nada.kth.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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