Linked Life Data

1079193

Source:http://linkedlifedata.com/resource/pubmed/id/1079193

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1975-7-31
pubmed:abstractText
Intranasal inoculation of M. pulmonis in mice and M. pneumoniae in hamsters results in pneumonia characterised by peribronchiolar and perivascular cuffing by lymphocytes. Thymus-dependent lymphocytes were depleted in mice by thymectomy and X-irradiation or treatment with anti-lymphocyte serum (ALS), and in hamsters by treatment with ALS. These procedures caused a reduction in the severity of pneumonic lesions in infected animals compared with infected immunologically normal animals. In addition, the organisms were present in slightly greater numbers in the lungs of the immunosuppressed animals. These results indicate the importance of thymus-dependent lymphocytes in the pathogenesis of mycoplasma-induced pulmonary disease. However, the role that these cells play in resistance to infection is not known and it may be that local secretory antibody is also important. Results of preliminary experiments involving hamster tracheal organ cultures infected with M. pneumoniae indicate that there is a factor present in lung washings from immune hamsters that protects against loss of ciliary activity brought about by M. pneumoniae.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5149
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-210
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
The part played by cell-mediated immunity in mycoplasma respiratory infections.
pubmed:publicationType
Journal Article, Comparative Study