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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2000-5-30
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pubmed:abstractText |
Receptors for immunoglobulin (Ig)G (FcgammaRs) are important for the antibody-mediated effector functions of the immune system. FcgammaRI and FcgammaRIII trigger cell activation through a common gamma chain, whereas FcgammaRII acts as a negative regulator of antibody production and immune complex-triggered activation. Here we describe the in vivo consequences of FcgammaR deficiency in a mouse model of human rheumatoid arthritis. FcRgamma chain-deficient mice on arthritis-susceptible DBA/1 background were immunized with collagen for induction of collagen-induced arthritis. The DBA/1 mice lacking FcRgamma chain were protected from collagen-induced arthritis in contrast to wild-type mice, although both groups produced similar levels of IgG anticollagen antibodies. In comparison, DBA/1 mice lacking FcgammaRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcgammaRI and FcgammaRIII in triggering autoimmune arthritis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-10201957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-10229188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-10395649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-1812893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-1968678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-4565026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-6095870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-6153460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-6792316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-6886622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-7621075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-8024611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-8031999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-8066448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-8313472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-8552190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-8843863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-9013945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-9528892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-9597136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-9692811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-9739057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-9874574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10790435-9874575
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
191
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1611-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10790435-Animals,
pubmed-meshheading:10790435-Antigens, CD,
pubmed-meshheading:10790435-Arthritis, Rheumatoid,
pubmed-meshheading:10790435-Immunity, Innate,
pubmed-meshheading:10790435-Mice,
pubmed-meshheading:10790435-Mice, Inbred DBA,
pubmed-meshheading:10790435-Mice, Mutant Strains,
pubmed-meshheading:10790435-Receptors, IgG
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pubmed:year |
2000
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pubmed:articleTitle |
Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors.
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pubmed:affiliation |
Department of Genetics and Pathology, Uppsala University, S-75185 Uppsala, Sweden. sandra.kleinau@genpat.uu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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