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rdf:type |
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lifeskim:mentions |
umls-concept:C0003483,
umls-concept:C0017337,
umls-concept:C0031727,
umls-concept:C0037083,
umls-concept:C0086418,
umls-concept:C0086860,
umls-concept:C0682972,
umls-concept:C0851285,
umls-concept:C0936012,
umls-concept:C1135918,
umls-concept:C1366490
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pubmed:issue |
17
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pubmed:dateCreated |
2000-5-16
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pubmed:abstractText |
Desensitization of G protein-coupled receptors (GPCR) is emerging as an important feature of several cardiovascular diseases. G protein-coupled receptor kinase 2 (GRK2) plays a key role in the regulation of a variety of these receptors, and its cardiac expression levels are altered in pathological situations such as chronic heart failure. However, very little is known about the signals and mechanisms that modulate GRK2 expression in cardiovascular cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2083-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10790351-Animals,
pubmed-meshheading:10790351-Aorta,
pubmed-meshheading:10790351-Cell Line,
pubmed-meshheading:10790351-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10790351-Cytokines,
pubmed-meshheading:10790351-G-Protein-Coupled Receptor Kinase 2,
pubmed-meshheading:10790351-Humans,
pubmed-meshheading:10790351-Muscle, Smooth, Vascular,
pubmed-meshheading:10790351-Phorbol Esters,
pubmed-meshheading:10790351-Promoter Regions, Genetic,
pubmed-meshheading:10790351-RNA, Messenger,
pubmed-meshheading:10790351-Rats,
pubmed-meshheading:10790351-Signal Transduction,
pubmed-meshheading:10790351-Transcription, Genetic,
pubmed-meshheading:10790351-Tumor Cells, Cultured,
pubmed-meshheading:10790351-beta-Adrenergic Receptor Kinases
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pubmed:year |
2000
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pubmed:articleTitle |
Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells.
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pubmed:affiliation |
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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