Source:http://linkedlifedata.com/resource/pubmed/id/10788693
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-8-22
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pubmed:abstractText |
Whole-cell/voltage-clamp recordings were made from dissociated bullfrog sympathetic neurons to examine the channel blocking actions of barium (3-2000 microM) on an M-type potassium current (I(M)). Barium (IC(50) approximately 105 microM) blocked I(M) without affecting the 50%-activation voltage ( approximately -35 mV) and the slope factor ( approximately 11 mV) of the activation curve. The results indicate that the barium block is independent of the kinetics of I(M).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
285
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10788693-Action Potentials,
pubmed-meshheading:10788693-Animals,
pubmed-meshheading:10788693-Autonomic Nerve Block,
pubmed-meshheading:10788693-Barium,
pubmed-meshheading:10788693-Neurons,
pubmed-meshheading:10788693-Patch-Clamp Techniques,
pubmed-meshheading:10788693-Potassium Channel Blockers,
pubmed-meshheading:10788693-Potassium Channels,
pubmed-meshheading:10788693-Rana catesbeiana,
pubmed-meshheading:10788693-Sympathetic Nervous System,
pubmed-meshheading:10788693-Sympatholytics
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pubmed:year |
2000
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pubmed:articleTitle |
Mechanisms underlying the M-current block by barium in bullfrog sympathetic neurons.
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pubmed:affiliation |
Department of Physiology, Tokai University School of Medicine, Bohseidai, Isehara, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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