|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002844,
umls-concept:C0017262,
umls-concept:C0021760,
umls-concept:C0040649,
umls-concept:C0040661,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C1515877,
umls-concept:C1704259,
umls-concept:C1705162,
umls-concept:C1705987,
umls-concept:C1710082,
umls-concept:C1879547
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2000-5-11
|
|
pubmed:abstractText |
Interleukin 6 (IL-6) is a cytokine that regulates not only immune and inflammatory responses but also the growth of some tumors, including prostate carcinomas. IL-6 signals through Janus kinase, signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinase and is also able to induce androgen receptor (AR)-mediated gene activation in prostate cancer, which is an important process in prostate cancer androgen-independent progression. We now show that IL-6-induced AR-mediated gene activation requires the activation of STAT3 by IL-6 in LNCaP prostate cancer cells. In particular, STAT3 associates with AR in an androgen-independent but IL-6-dependent manner. Inhibition of STAT3 rather than mitogen-activated protein kinase results in inhibition of AR-mediated gene activation in response to IL-6. These findings not only identify STAT3 as an important signaling molecule required for IL-6-signaling to induce AR-mediated gene activation in prostate carcinoma cells but also reveal the importance of activated STAT3 in human tumor development and progression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Metribolone,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SOCS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SOCS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone Congeners,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0008-5472
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2132-5
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10786674-Carrier Proteins,
pubmed-meshheading:10786674-DNA-Binding Proteins,
pubmed-meshheading:10786674-Disease Progression,
pubmed-meshheading:10786674-Enzyme Activation,
pubmed-meshheading:10786674-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10786674-Genes, Reporter,
pubmed-meshheading:10786674-Humans,
pubmed-meshheading:10786674-Interleukin-6,
pubmed-meshheading:10786674-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:10786674-Janus Kinase 2,
pubmed-meshheading:10786674-Male,
pubmed-meshheading:10786674-Metribolone,
pubmed-meshheading:10786674-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10786674-Mutation,
pubmed-meshheading:10786674-Prostatic Neoplasms,
pubmed-meshheading:10786674-Protein Binding,
pubmed-meshheading:10786674-Protein-Tyrosine Kinases,
pubmed-meshheading:10786674-Proteins,
pubmed-meshheading:10786674-Proto-Oncogene Proteins,
pubmed-meshheading:10786674-Receptors, Androgen,
pubmed-meshheading:10786674-Repressor Proteins,
pubmed-meshheading:10786674-Response Elements,
pubmed-meshheading:10786674-STAT3 Transcription Factor,
pubmed-meshheading:10786674-Signal Transduction,
pubmed-meshheading:10786674-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:10786674-Testosterone Congeners,
pubmed-meshheading:10786674-Trans-Activators,
pubmed-meshheading:10786674-Transcriptional Activation,
pubmed-meshheading:10786674-Transfection,
pubmed-meshheading:10786674-Tumor Cells, Cultured
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.
|
|
pubmed:affiliation |
Intramural Research Support Program, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
