10785413

Source:http://linkedlifedata.com/resource/pubmed/id/10785413

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205198, umls-concept:C2761402
pubmed:issue	4
pubmed:dateCreated	2000-6-23
pubmed:abstractText	A methanol extract of Combretum erythrophyllum showed inhibitory bioactivities in a yeast-based microtiter assay for DNA-damaging agents. Bioassay-guided fractionation of this extract yielded two known bioactive compounds, combretastatin A-1 and (-)-combretastatin, and two new bioactive glucosides, combretastatin A-1 2'-beta-D-glucoside (1) and combretastatin B-1 2'-beta-D-glucoside (2). The structures of the new compounds were assigned by (1)H and (13)C NMR, DEPT, HMQC, and HMBC spectra.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/U19 CA 50771
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/10785413
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7906882
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic, http://linkedlifedata.com/resource/pubmed/chemical/Bibenzyls, http://linkedlifedata.com/resource/pubmed/chemical/Glycosides, http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts, http://linkedlifedata.com/resource/pubmed/chemical/Stilbenes, http://linkedlifedata.com/resource/pubmed/chemical/combretastatin, http://linkedlifedata.com/resource/pubmed/chemical/combretastatin A-1
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0163-3864
pubmed:author	pubmed-author:GlassT ETE, pubmed-author:JohnsonR KRK, pubmed-author:KingstonD GDG, pubmed-author:MatternM RMR, pubmed-author:SchwikkardSS, pubmed-author:SharpJ LJL, pubmed-author:ZhouB NBN
pubmed:issnType	Print
pubmed:volume	63
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	457-60
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:10785413-Antineoplastic Agents, Phytogenic, pubmed-meshheading:10785413-Bibenzyls, pubmed-meshheading:10785413-Carbohydrate Sequence, pubmed-meshheading:10785413-DNA Damage, pubmed-meshheading:10785413-DNA Repair, pubmed-meshheading:10785413-Drug Screening Assays, Antitumor, pubmed-meshheading:10785413-Glycosides, pubmed-meshheading:10785413-Humans, pubmed-meshheading:10785413-Magnetic Resonance Spectroscopy, pubmed-meshheading:10785413-Mass Spectrometry, pubmed-meshheading:10785413-Molecular Sequence Data, pubmed-meshheading:10785413-Plant Extracts, pubmed-meshheading:10785413-Plants, Medicinal, pubmed-meshheading:10785413-South Africa, pubmed-meshheading:10785413-Spectrophotometry, Ultraviolet, pubmed-meshheading:10785413-Stilbenes, pubmed-meshheading:10785413-Tumor Cells, Cultured, pubmed-meshheading:10785413-Wood
pubmed:year	2000
pubmed:articleTitle	Bioactive compounds from Combretum erythrophyllum.
pubmed:affiliation	Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't