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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-6-23
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pubmed:abstractText |
Chemical investigation of the Et(2)O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human bronchopulmonary cancer cells (NSCLC-N6) with an IC(50) of 12 and 6.3 microg/mL, respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10785411-Animals,
pubmed-meshheading:10785411-Antineoplastic Agents,
pubmed-meshheading:10785411-Cell Division,
pubmed-meshheading:10785411-Chromatography, High Pressure Liquid,
pubmed-meshheading:10785411-Drug Screening Assays, Antitumor,
pubmed-meshheading:10785411-Imidazoles,
pubmed-meshheading:10785411-Indoles,
pubmed-meshheading:10785411-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10785411-Piperazines,
pubmed-meshheading:10785411-Porifera,
pubmed-meshheading:10785411-Spectrophotometry, Ultraviolet,
pubmed-meshheading:10785411-Tissue Extracts,
pubmed-meshheading:10785411-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.
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|
pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, via Ponte Don Melillo, Fisciano (SA) 84084, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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