Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-7-17
pubmed:abstractText
Glutamic acid decarboxylase (GAD), the enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), is a target of humoral autoimmunity in stiff-man syndrome and subacute cerebellar ataxia. Recently, we found that an anti-GAD autoantibody in the CSF of an ataxic patient selectively suppressed GABA-mediated transmission on cerebellar Purkinje cells without affecting glutamate-mediated transmission. Here, we examine the mechanism by which the autoantibody impaired the inhibitory transmission, using immunohistochemistry and whole-cell recording in rat cerebellar slices. The present results indicate that CSF immunoglobulins prepared from an ataxic patient acted on the presynaptic terminals of GABAergic interneurons and decreased GABA release onto Purkinje cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
175
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:10785255-Action Potentials, pubmed-meshheading:10785255-Aged, pubmed-meshheading:10785255-Animals, pubmed-meshheading:10785255-Autoantibodies, pubmed-meshheading:10785255-Bicuculline, pubmed-meshheading:10785255-Calcium, pubmed-meshheading:10785255-Calcium-Binding Protein, Vitamin D-Dependent, pubmed-meshheading:10785255-Calcium-Binding Proteins, pubmed-meshheading:10785255-Cerebellar Ataxia, pubmed-meshheading:10785255-Cerebellar Cortex, pubmed-meshheading:10785255-Female, pubmed-meshheading:10785255-GABA Antagonists, pubmed-meshheading:10785255-Glutamate Decarboxylase, pubmed-meshheading:10785255-Humans, pubmed-meshheading:10785255-Immunoglobulin G, pubmed-meshheading:10785255-Nerve Tissue Proteins, pubmed-meshheading:10785255-Neural Inhibition, pubmed-meshheading:10785255-Presynaptic Terminals, pubmed-meshheading:10785255-Purkinje Cells, pubmed-meshheading:10785255-Rats, pubmed-meshheading:10785255-Stiff-Person Syndrome, pubmed-meshheading:10785255-Synaptic Transmission, pubmed-meshheading:10785255-gamma-Aminobutyric Acid
pubmed:year
2000
pubmed:articleTitle
Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase.
pubmed:affiliation
Mitoma Neurological Clinic, 1-2-10 Minami-Ikebukuro, Toshima-ku, Tokyo, Japan.
pubmed:publicationType
Journal Article