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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-9-21
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pubmed:abstractText |
While IL-12 administration induces tumor regression through stimulating T cells in tumor-bearing mice, this IL-12 effect is observed in some but not all tumor models. The present study aimed to compare IL-12 responsiveness of T cells from tumor-bearing mice in IL-12-responsive (CSA1M and OV-HM) and -unresponsive (Meth A) tumor models. Tumor regression in IL-12-responsive tumor models required the participation of T cells, but not of NK1.1(+) cells. Because a NK1.1(+) cell population was the major producer of IFN-gamma, comparable levels of IFN-gamma production were induced in IL-12-responsive and -unresponsive tumor-bearing mice. This indicates that the amount of IFN-gamma produced in tumor-bearing individuals does not correlate with the anti-tumor efficacy of IL-12. In contrast, IL-12 responsiveness of T cells differed between the responsive and unresponsive models: purified T cells from CSA1M/OV-HM-bearing or Meth A-bearing mice exhibited high or low IL-12 responsiveness respectively, when evaluated by the amounts of IFN-gamma produced in response to IL-12. T cells from CSA1M- or OV-HM-bearing but not from Meth A-bearing mice exhibited enhanced levels of mRNA for the IL-12 receptor (IL-12R). These results indicate that a fundamental difference exists in IL-12 responsiveness of T cells between IL-12-responsive and -unresponsive tumor models, and that such a difference is associated with the expression of IL-12R on T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Klrb1c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
701-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10784616-Animals,
pubmed-meshheading:10784616-Antigens,
pubmed-meshheading:10784616-Antigens, Ly,
pubmed-meshheading:10784616-Antigens, Surface,
pubmed-meshheading:10784616-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10784616-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10784616-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10784616-Female,
pubmed-meshheading:10784616-Interferon-gamma,
pubmed-meshheading:10784616-Interleukin-12,
pubmed-meshheading:10784616-Killer Cells, Natural,
pubmed-meshheading:10784616-Lectins, C-Type,
pubmed-meshheading:10784616-Male,
pubmed-meshheading:10784616-Mice,
pubmed-meshheading:10784616-Mice, Inbred BALB C,
pubmed-meshheading:10784616-Mice, Inbred C3H,
pubmed-meshheading:10784616-Mice, Inbred C57BL,
pubmed-meshheading:10784616-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:10784616-Neoplasms, Experimental,
pubmed-meshheading:10784616-Proteins,
pubmed-meshheading:10784616-RNA, Messenger,
pubmed-meshheading:10784616-Receptors, Interleukin,
pubmed-meshheading:10784616-Receptors, Interleukin-12,
pubmed-meshheading:10784616-Spleen,
pubmed-meshheading:10784616-T-Lymphocytes,
pubmed-meshheading:10784616-Time Factors,
pubmed-meshheading:10784616-Tumor Cells, Cultured,
pubmed-meshheading:10784616-Tumor Escape
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pubmed:year |
2000
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pubmed:articleTitle |
Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models.
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pubmed:affiliation |
Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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