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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-7-13
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pubmed:abstractText |
In the process development of lovastatin using Aspergillus terreus DRCC 152 in solid state fermentation, we have isolated a new butyrolactone-IV (3) along with the previously reported butyrolactone-I (1) and butyrolactone-II (2) produced under submerged conditions. The structure of compound 3 has been characterized as 3-hydroxy-5-[2-(1-hydroxy-1-methylethyl)-2(R)-2,3-dihydro-benzo[b]furan- 5 ylmethyl]-4-(4-hydroxyphenyl)-5-methoxycarbonyl-(5R)-2,5-dihydro-2 -furanone on the basis of spectroscopic studies. The absolute stereochemistry has been determined by single crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of these compounds were determined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0009-2363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
559-62
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10783079-4-Butyrolactone,
pubmed-meshheading:10783079-Animals,
pubmed-meshheading:10783079-Anti-Bacterial Agents,
pubmed-meshheading:10783079-Anti-Infective Agents,
pubmed-meshheading:10783079-Antineoplastic Agents,
pubmed-meshheading:10783079-Aspergillus,
pubmed-meshheading:10783079-Bacillus subtilis,
pubmed-meshheading:10783079-Enterococcus faecalis,
pubmed-meshheading:10783079-Escherichia coli,
pubmed-meshheading:10783079-Fermentation,
pubmed-meshheading:10783079-Microbial Sensitivity Tests,
pubmed-meshheading:10783079-Models, Chemical,
pubmed-meshheading:10783079-Models, Molecular,
pubmed-meshheading:10783079-Pseudomonas aeruginosa,
pubmed-meshheading:10783079-Staphylococcus aureus,
pubmed-meshheading:10783079-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Butyrolactones from Aspergillus terreus.
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pubmed:affiliation |
Dr Reddy's Research Foundation, Miyapur, Hyderabad, India.
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pubmed:publicationType |
Journal Article
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