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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-6-20
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pubmed:abstractText |
Analogues of sarilesin (type I AT1 antagonists), and sarmesin (type II AT1 antagonists) with homoserine (hSer) at position 8 were prepared and bioassayed. The presence of a Tyr4-Ile5-His6 bend found in sarmesin but not in sarilesin was identified. The obtained results coupled with conformational analysis studies, using a combination of NMR spectroscopy and computational chemistry, propose important conformational and stereoelectronic properties for agonist and antagonist activity at AT1 receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
755-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10782679-Angiotensin I,
pubmed-meshheading:10782679-Angiotensin II,
pubmed-meshheading:10782679-Angiotensin Receptor Antagonists,
pubmed-meshheading:10782679-Animals,
pubmed-meshheading:10782679-Drug Design,
pubmed-meshheading:10782679-Female,
pubmed-meshheading:10782679-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10782679-Models, Molecular,
pubmed-meshheading:10782679-Rats,
pubmed-meshheading:10782679-Receptors, Angiotensin,
pubmed-meshheading:10782679-Structure-Activity Relationship,
pubmed-meshheading:10782679-Uterus
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pubmed:year |
2000
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pubmed:articleTitle |
Structural comparison between type I and type II antagonists: possible implications in the drug design of AT1 antagonists.
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pubmed:affiliation |
Department of Chemistry, University of Patras, Greece.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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