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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
27
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pubmed:dateCreated |
2000-8-16
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pubmed:abstractText |
In the search for physiological substrates of MAPK-activated protein (MAPKAP) kinases, we identified the basic helix-loop-helix (bHLH) transcription factor E47 as an interaction partner of chromosome 3p kinase (3pK) and MAPKAP-K2 (MK2). The E2A protein E47 is known to be involved in the regulation of tissue-specific gene expression and cell differentiation. E47 is a phosphoprotein, and we identified 3pK and MK2 as E47 kinases in vitro. Furthermore, the expression of either kinase results in a repression of the transcriptional activity of E47 on an E-box containing promoter. In summary, the MAPK-activated protein kinases 3pK and MK2 were identified to form an assembly with the bHLH protein E47 suggesting that these kinases are regulators of E47 activity and E47-dependent gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/MAP-kinase-activated kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TCF Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/TCF7L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor 7-Like 1...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
275
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20239-42
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10781029-Animals,
pubmed-meshheading:10781029-Base Sequence,
pubmed-meshheading:10781029-Cell Line,
pubmed-meshheading:10781029-DNA-Binding Proteins,
pubmed-meshheading:10781029-Gene Expression Regulation,
pubmed-meshheading:10781029-Genes, Reporter,
pubmed-meshheading:10781029-Humans,
pubmed-meshheading:10781029-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:10781029-MAP Kinase Kinase 2,
pubmed-meshheading:10781029-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:10781029-Molecular Sequence Data,
pubmed-meshheading:10781029-Phosphorylation,
pubmed-meshheading:10781029-Precipitin Tests,
pubmed-meshheading:10781029-Promoter Regions, Genetic,
pubmed-meshheading:10781029-Protein Binding,
pubmed-meshheading:10781029-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10781029-Protein-Tyrosine Kinases,
pubmed-meshheading:10781029-Recombinant Proteins,
pubmed-meshheading:10781029-Repressor Proteins,
pubmed-meshheading:10781029-TCF Transcription Factors,
pubmed-meshheading:10781029-Transcription Factor 7-Like 1 Protein,
pubmed-meshheading:10781029-Transcription Factors,
pubmed-meshheading:10781029-Transcriptional Activation,
pubmed-meshheading:10781029-Transfection,
pubmed-meshheading:10781029-Yeasts
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pubmed:year |
2000
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pubmed:articleTitle |
Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity.
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pubmed:affiliation |
Institut für Medizinische Strahlenkunde und Zellforschung, Universität Würzburg, Versbacher Strasse 5, 97078 Würzburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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