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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-6-30
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pubmed:abstractText |
Ibogaine and 18-methoxycoronaridine are naturally occurring alkaloids reported to possess antiaddictive properties in several models of drug dependence. We have examined their effect at mu-opioid receptors regulating neurogenic contractions of several smooth muscle preparations and also against spontaneous contractions of the rat isolated portal vein. Ibogaine (pIC(50) 5.28) and 18-methoxycoronaridine (pIC(50) 5.05) caused a concentration-dependent inhibition of cholinergic contractions of the guinea-pig ileum which was not affected by the opioid receptor antagonist naloxone (1 microM). In the rat isolated vas deferens ibogaine and 18-methoxycoronaridine caused a concentration-dependent enhancement of purinergic contractions. Both agents (30 microM) caused a 3 - 5 fold rightward displacement of DAMGO-induced inhibition of purinergic contractions, but similar effects were observed for ibogaine against alpha(2)-adrenoceptor-mediated inhibition of neurogenic responses. In the guinea-pig isolated bladder both ibogaine (10 microM) and 18-methoxycoronaridine (10 microM) caused a 2 fold increase in the purinergic component of neurogenic contractions without significantly altering cholinergic contractions or responses to exogenous ATP. In contrast, ibogaine (1 - 30 microM), but not 18-methoxycoronaridine, caused a concentration-dependent enhancement of spontaneous contractions of the rat isolated portal vein. In summary, while ibogaine and 18-methoxycoronaridine modulated electrically-evoked contractions in the three preparations examined, we have no evidence for a selective interaction with pre-junctional mu-opioid receptors. The pronounced enhancement of purinergic contractions produced by both agents is a novel finding and worthy of further investigation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-1377086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-1661836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-1868880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-1893925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-206115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-2331585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-2851350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-28558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-2908125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-3359103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-3801765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-4202581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-5499824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-6263640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-6297936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-6676107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-686171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-7238569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-7568327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-7568622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-7796150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-7820611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-8243561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-8646423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-8725004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-8782860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-8887732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-8982706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-8995326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-9001731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-9138735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-9351497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780959-9592058
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1561-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10780959-Animals,
pubmed-meshheading:10780959-Dose-Response Relationship, Drug,
pubmed-meshheading:10780959-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10780959-Guinea Pigs,
pubmed-meshheading:10780959-Ibogaine,
pubmed-meshheading:10780959-Ileum,
pubmed-meshheading:10780959-Male,
pubmed-meshheading:10780959-Muscle, Smooth,
pubmed-meshheading:10780959-Muscle Contraction,
pubmed-meshheading:10780959-Portal Vein,
pubmed-meshheading:10780959-Rats,
pubmed-meshheading:10780959-Urinary Bladder,
pubmed-meshheading:10780959-Vas Deferens
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pubmed:year |
2000
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pubmed:articleTitle |
Pharmacological comparison of the effect of ibogaine and 18-methoxycoronaridine on isolated smooth muscle from the rat and guinea-pig.
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pubmed:affiliation |
School of Biomedical Sciences, The Medical School, E. Floor, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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