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pubmed-article:10780928pubmed:abstractTextBasic helix-loop-helix (bHLH) transcription factors are characterized by a conserved four-helix bundle that recognizes a specific hexanucleotide DNA sequence in the major groove. Previous studies have shown that amino acids in the basic region make base-specific contacts, whereas the HLH region is responsible for dimerization. Structural data suggest that portions of the loop region may be proximal to the DNA; however, the role of the loop in DNA-binding affinity and specificity has not been investigated.lld:pubmed
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pubmed-article:10780928pubmed:articleTitleRapid identification of key amino-acid-DNA contacts through combinatorial peptide synthesis.lld:pubmed
pubmed-article:10780928pubmed:affiliationDepartment of Molecular Biology, The Scripps Research Institute, University of California, La Jolla, Berkeley, CA 92037, USA.lld:pubmed
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