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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-5-16
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pubmed:abstractText |
Basic helix-loop-helix (bHLH) transcription factors are characterized by a conserved four-helix bundle that recognizes a specific hexanucleotide DNA sequence in the major groove. Previous studies have shown that amino acids in the basic region make base-specific contacts, whereas the HLH region is responsible for dimerization. Structural data suggest that portions of the loop region may be proximal to the DNA; however, the role of the loop in DNA-binding affinity and specificity has not been investigated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-51
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10780928-Amino Acid Sequence,
pubmed-meshheading:10780928-Amino Acids,
pubmed-meshheading:10780928-Animals,
pubmed-meshheading:10780928-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:10780928-Binding Sites,
pubmed-meshheading:10780928-Chromatography, Affinity,
pubmed-meshheading:10780928-Combinatorial Chemistry Techniques,
pubmed-meshheading:10780928-DNA-Binding Proteins,
pubmed-meshheading:10780928-Dimerization,
pubmed-meshheading:10780928-Drosophila,
pubmed-meshheading:10780928-Drosophila Proteins,
pubmed-meshheading:10780928-Helix-Loop-Helix Motifs,
pubmed-meshheading:10780928-Molecular Sequence Data,
pubmed-meshheading:10780928-Nuclear Proteins,
pubmed-meshheading:10780928-Peptide Library,
pubmed-meshheading:10780928-Peptides,
pubmed-meshheading:10780928-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:10780928-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Rapid identification of key amino-acid-DNA contacts through combinatorial peptide synthesis.
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pubmed:affiliation |
Department of Molecular Biology, The Scripps Research Institute, University of California, La Jolla, Berkeley, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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