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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-5-9
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pubmed:abstractText |
High microvessel density, an indirect measure of angiogenesis, has been shown to correlate with increased tumour size, lymph node involvement and poor prognosis in non-small-cell lung cancer (NSCLC). Tumour cell vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) expression correlate with angiogenesis and a poor outcome in this disease. In a retrospective study VEGF and PD-ECGF expression and microvessel density were evaluated immunohistochemically in surgically resected specimens (T1-3, N0-2) from 223 patients with operable NSCLC using the VG1, P-GF.44C and JC70 monoclonal antibodies respectively. High VEGF immunoreactivity was seen in 104 (46.6%) and PD-ECGF in 72 (32.3%) cases and both were associated with high vascular grade tumours (P= 0.009 and P= 0.05 respectively). Linear regression analysis revealed a weak positive correlation between VEGF and PD-ECGF expression in cancer cells (r= 0.21; P = 0.002). Co-expression of VEGF and PD-ECGF was not associated with a higher microvessel density than VEGF or PD-ECGF only expressing tumours. Furthermore a proportion of high vascular grade tumours expressed neither growth factor. Univariate analysis revealed tumour size, nodal status, microvessel density and VEGF and PD-ECGF expression as significant prognostic factors. Tumour size (P < 0.02) and microvessel density (P < 0.04) remained significant on multivariate analysis. In conclusion, VEGF and PD-ECGF are important angiogenic growth factors and have prognostic significance in NSCLC. Furthermore the study underlines the prognostic significance of microvessel density in operable NSCLC.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780522-10100701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780522-10188906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10780522-10211122,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10780522-9888482
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1427-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10780522-Adenocarcinoma,
pubmed-meshheading:10780522-Analysis of Variance,
pubmed-meshheading:10780522-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:10780522-Carcinoma, Squamous Cell,
pubmed-meshheading:10780522-Endothelial Growth Factors,
pubmed-meshheading:10780522-Humans,
pubmed-meshheading:10780522-Immunohistochemistry,
pubmed-meshheading:10780522-Lung Neoplasms,
pubmed-meshheading:10780522-Lymphokines,
pubmed-meshheading:10780522-Microcirculation,
pubmed-meshheading:10780522-Neoplasm Staging,
pubmed-meshheading:10780522-Neovascularization, Pathologic,
pubmed-meshheading:10780522-Observer Variation,
pubmed-meshheading:10780522-Prognosis,
pubmed-meshheading:10780522-Protein Isoforms,
pubmed-meshheading:10780522-Survival Analysis,
pubmed-meshheading:10780522-Thymidine Phosphorylase,
pubmed-meshheading:10780522-Vascular Endothelial Growth Factor A,
pubmed-meshheading:10780522-Vascular Endothelial Growth Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer.
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pubmed:affiliation |
University Department of Oncology, Leicester Royal Infirmary, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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