| pubmed-article:10779756 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1516670 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C0870432 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1705417 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1555465 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:10779756 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:10779756 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10779756 | pubmed:dateCreated | 2000-5-22 | lld:pubmed |
| pubmed-article:10779756 | pubmed:abstractText | It is thought that protective immunity is mediated in part by Ag-experienced T cells that respond more quickly and vigorously than naive T cells. Using adoptive transfer of OVA-specific CD4 T cells from TCR transgenic mice as a model system, we show that Ag-experienced CD4 T cells accumulate in lymph nodes more rapidly than naive T cells after in vivo challenge with Ag. However, the magnitude of clonal expansion by Ag-experienced T cells was much less than that of naive T cells, particularly at early times after primary immunization. Ag-experienced CD4 T cells quickly reverted to the slower but more robust clonal expansion behavior of naive T cells after transfer into a naive environment. Conversely, the capacity for rapid clonal expansion was acquired by naive CD4 T cells after transfer into passively immunized recipients. These results indicate that rapid in vivo response by Ag-experienced T cells is facilitated by Ag-specific Abs, whereas the limited capacity for clonal expansion is imposed by some other factor in the immune environment, perhaps residual Ag. | lld:pubmed |
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| pubmed-article:10779756 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10779756 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10779756 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10779756 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10779756 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10779756 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10779756 | pubmed:month | May | lld:pubmed |
| pubmed-article:10779756 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10779756 | pubmed:author | pubmed-author:JenkinsM KMK | lld:pubmed |
| pubmed-article:10779756 | pubmed:author | pubmed-author:KhorutsAA | lld:pubmed |
| pubmed-article:10779756 | pubmed:author | pubmed-author:PapeK AKA | lld:pubmed |
| pubmed-article:10779756 | pubmed:author | pubmed-author:ReinhardtR... | lld:pubmed |
| pubmed-article:10779756 | pubmed:author | pubmed-author:MericaRR | lld:pubmed |
| pubmed-article:10779756 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10779756 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10779756 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10779756 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10779756 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10779756 | pubmed:pagination | 4551-7 | lld:pubmed |
| pubmed-article:10779756 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:10779756 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10779756 | pubmed:articleTitle | Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. | lld:pubmed |
| pubmed-article:10779756 | pubmed:affiliation | Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. | lld:pubmed |
| pubmed-article:10779756 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10779756 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10779756 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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