Source:http://linkedlifedata.com/resource/pubmed/id/10779756
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2000-5-22
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| pubmed:abstractText |
It is thought that protective immunity is mediated in part by Ag-experienced T cells that respond more quickly and vigorously than naive T cells. Using adoptive transfer of OVA-specific CD4 T cells from TCR transgenic mice as a model system, we show that Ag-experienced CD4 T cells accumulate in lymph nodes more rapidly than naive T cells after in vivo challenge with Ag. However, the magnitude of clonal expansion by Ag-experienced T cells was much less than that of naive T cells, particularly at early times after primary immunization. Ag-experienced CD4 T cells quickly reverted to the slower but more robust clonal expansion behavior of naive T cells after transfer into a naive environment. Conversely, the capacity for rapid clonal expansion was acquired by naive CD4 T cells after transfer into passively immunized recipients. These results indicate that rapid in vivo response by Ag-experienced T cells is facilitated by Ag-specific Abs, whereas the limited capacity for clonal expansion is imposed by some other factor in the immune environment, perhaps residual Ag.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
164
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4551-7
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| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:10779756-Adoptive Transfer,
pubmed-meshheading:10779756-Animals,
pubmed-meshheading:10779756-Antibodies,
pubmed-meshheading:10779756-Antibody Specificity,
pubmed-meshheading:10779756-Antigens,
pubmed-meshheading:10779756-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10779756-Clone Cells,
pubmed-meshheading:10779756-Epitopes, T-Lymphocyte,
pubmed-meshheading:10779756-Immunization, Secondary,
pubmed-meshheading:10779756-Injections, Intravenous,
pubmed-meshheading:10779756-Lymph Nodes,
pubmed-meshheading:10779756-Lymphocyte Activation,
pubmed-meshheading:10779756-Mice,
pubmed-meshheading:10779756-Mice, Inbred BALB C,
pubmed-meshheading:10779756-Mice, SCID,
pubmed-meshheading:10779756-Mice, Transgenic,
pubmed-meshheading:10779756-Ovalbumin,
pubmed-meshheading:10779756-Receptors, Antigen, T-Cell
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host.
|
| pubmed:affiliation |
Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|