Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-6-9
pubmed:abstractText
Our challenge in annotating the 2.91-Mb Adh region of the Drosophila melanogaster genome was to identify genetic and genomic features automatically, completely, and precisely within a 6-week period. To do so, we augmented the MAGPIE microbial genome annotation system to handle eukaryotic genomic sequence data. The new configuration required the integration of eukaryotic gene-finding tools and DNA repeat tools into the automatic data collection module. It also required us to define in MAGPIE new strategies to combine data about eukaryotic exon predictions with functional data to refine the exon predictions. At the heart of the resulting new eukaryotic genome annotation system is a reverse comparison of public protein and complementary DNA sequences against the input genome to identify missing exons and to refine exon boundaries. The software modules that add eukaryotic genome annotation capability to MAGPIE are available as EGRET (Eukaryotic Genome Rapid Evaluation Tool).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-10049392, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-10366664, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-10427000, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-10471707, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-10547837, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-10779478, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-8905148, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-9254694, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-9537320, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-9666331, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-9847184, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-9847185, http://linkedlifedata.com/resource/pubmed/commentcorrection/10779489-9847186
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1088-9051
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
502-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
MAGPIE/EGRET annotation of the 2.9-Mb Drosophila melanogaster Adh region.
pubmed:affiliation
The Rockefeller University, Laboratory of Computational Genomics, New York, New York 10021, USA. gaasterl@genomes.rockefeller.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't